Evaluation of Optical Coherence Tomography in Dentistry

Condition(s) studied

Investigational drug(s) / intervention(s)

Transbond XT: Application of • Transbond XT (activator comparator) to labial surfaces of teeth of randomized quadrants.

Protecto®CaF2Nano: Application of • Protecto®CaF2Nano (orthodontic surface sealant) to labial surfaces of teeth of randomized quadrants.

Pro Seal®: Application of • Protecto®CaF2Nano (orthodontic surface sealant) to labial surfaces of teeth of randomized quadrants.

Opal®Seal: Application of • Opal®Seal (orthodontic surface sealant) to labial surfaces of teeth of randomized quadrants.

Study summary

Optical coherence tomography (OCT) is a medical diagnostic tool, providing non-invasive, non-radiative and high resolution imaging. OCT has been established since many years in ophthalmology. In dentistry the diagnostic potential of OCT is currently increasingly being noticed. This clinical study includes two individual trials: (i) Longitudinal assessment of surface sealant thickness using optical coherence tomography and (ii) comparison of crevicular fluid levels of inflammatory cytokines after the application of surface sealants.

Eligibility

Primary outcome measure(s)

• Abrasion behaviour of orthodontic surface sealants — The thickness changes of the orthodontic surface sealants and the development of enamel demineralization will be monitored at the day of the application and five additional time points (t1= 1 month, t2= 3 months, t3= 6 months, t4=9 months, t5= 12 months)
  Longitudinal assesment of surface sealant thickness using optical coherence tomography

Trial sites (1)

More University of Heidelberg Medical Center trials in Germany