Disease Trajectories and Anti-cytokine Response Signatures in Atopic Dermatitis and Psoriasis

Condition(s) studied

Investigational drug(s) / intervention(s)

Biosampling for molecular analysis: Observational study with no therapeutic intervention. Biosampling for molecular analysis

Study summary

The clinical study investigates the long-term course of disease in patients with chronic inflammatory skin diseases (atopic eczema and psoriasis) and the impact of tarheted therapies on the clinical and molecular level. For this purpose, patients are asked to take part in regular examinations and data collections, and to donate biomaterials (blood, skin biopsies, skin swabs, tape strips, stool samples). Blood samples are used to analyze inflammation messengers. Punch biopsies from lesional and non-lesional skin areas are used to analyze gene expression. Tape strips are pieces of transparent adhesive tapes to strip off most of the horny layer that will be used to examine mRNA and protein expression. The skin smears are superficial smears of three areas of skin with cotton swabs, which are used to examine bacteria on the skin. Overall, the study will help to monitor the disease course clinically and on the molecular level in participating patients for at least ten years and to collect information about the impact of various external factors including treatments. The study has no effect on the therapies of the disease, it serves only the accompanying data collection

Eligibility

Primary outcome measure(s)

• Disease progression — 10 years
  Epidemiological and phenotypical data of patients
• Molecular signature changes — 10 years
  Molecular signatures will be measured using OMICS and sequencing technologies

Trial sites (1)

More University Hospital Schleswig-Holstein trials in Germany

Other trials for the same condition