Pediatric Arm of DZL All Age Asthma Cohort

NCT02496468 · tracked via the Priya Life Science Germany tracker

Sponsor

LMU Klinikum

Phase

Observational

Started

2013-01

Last updated

2024-08-28

Condition(s) studied

AsthmaWheezeHypersensitivityEndophenotype

Study summary

Despite its common occurrence, still little is known about pathomechanisms determining different wheeze and asthma trajectories and phenotypes in children, and those beginning in adulthood. Therefore, deciphering underlying determinants for different childhood and adult asthma phenotypes is urgently needed to develop personalized treatment approaches targeting distinct underlying mechanisms. Thereby, secondary prevention early in the disease process can also be achieved. The decoding of such mechanisms and their translation to the individual patient is the aim of the Disease Area Asthma Allergy of the 'German Centre for Lung Research' (DZL).

Eligibility

Sex

ALL

Min age

6 Months

Max age

18 Years

Healthy volunteers

Accepted

Inclusion Criteria: * informed consent by parents (and by children if age \> 8 years) * age 6 months to 18 years * term delivery (≥ 37 weeks) * active/passive understanding of German * age 6 months - \< 6 years: preschool wheeze (more than two episodes of wheeze during 12 months prior to inclusion) * age at least 6 years: doctor diagnosed asthma (according to current guidelines) Exclusion Criteria: * known inborn or perinatal pulmonary disease * airway malformation * oxygen therapy after birth with a duration of more than 24 hours * ventilator support or mechanical ventilation after birth * diagnoses of cystic fibrosis; primary ciliary dyskinesia * heart failure diagnosed after birth affecting pulmonary circulation * major respiratory diseases such as e.g. interstitial lung disease * any current non-atopic comorbidity * fever of at least 38.5°C during the last two weeks prior to the planned first visit

Primary outcome measure(s)

Prevalence of asthma — At baseline and during yearly follow-ups up to 2 years
Study participants will be assessed with regard to their development of asthma.
Prevalence of transient preschool wheeze — At baseline and during yearly follow-ups up to 2 years
Study participants will be assessed with regard to their development of transient preschool wheeze.

Trial sites (5)

Facility	City	Region	Status
University Children's Hospital Cologne, Department of Paediatric Allergology and Pneumology	Cologne	Germany	Recruiting
Medizinische Hochschule Hannover, Biomedical Research in Endstage and Obstructive Lung Disease	Hanover	Germany	Recruiting
Universitaetsklinikum Schleswig-Holstein, Klinik für Kinder- und Jugendmedizin, Airway Research Center North	Lübeck	Germany	Recruiting
Klinik für Kinder- und Jugendmedizin, Universitaetsklinikum Giessen und Marburg GmbH, Universities of Giessen and Marburg Lung Center	Marburg	Germany	Recruiting
Klinikum der Universitaet Muenchen, Comprehensive Pulmonary Center Munich	Munich	Germany	Recruiting

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A Study to Investigate GB-0895 in Adults With Mild to Moderate Asthma or COPD Active, not recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT02496468 on ClinicalTrials.gov ↗ ← All trials in Germany