Cerebellar Mutism Syndrome Study

NCT02300766 · tracked via the Priya Life Science Germany tracker

Sponsor

Rigshospitalet, Denmark

Phase

Observational

Started

2014-10

Last updated

2026-08-12

Condition(s) studied

Infratentorial NeoplasmsMutism

Study summary

The purpose of this study is to determine why up to 25% of the pediatric patients who have surgery for a tumor in the posterior fossa develops the Cerebellar Mutism Syndrome (CMS). Furthermore the purpose is to explore the clinical course and the best treatment of the syndrome.

Eligibility

Sex

ALL

Min age

—

Max age

18 Years

Healthy volunteers

Inclusion Criteria: * Age \< 18 years at the date of first imaging showing this tumour * Tumour in the cerebellum/4th ventricle/brainstem with intention to treat with surgical resection or open biopsy. Second and further surgeries are also included. * Informed consent from custodial parent(s) Exclusion Criteria: * None

Primary outcome measure(s)

Development and progress of Cerebellar Mutism Syndrome — 1 year after surgery
The development of CMS is determined by a survey developed Robertson et al. The correlation between the risk of developing CMS and different neurosurgical techniques, genomic variants, treatments, tumor types, comorbidities, neuroradiologic findings, handedness and preoperative language status will be explored.

Trial sites (32)

Facility	City	Region	Status
Medical University of Vienna	Vienna	Austria	Recruiting
University Hospital Leuven	Leuven	Belgium	Recruiting
Motol University Hospital	Prague	Czechia	Recruiting
Aalborg University Hospital	Aalborg	Denmark	Recruiting
Aarhus University Hospital	Aarhus	Denmark	Recruiting
Rigshospitalet	Copenhagen	Denmark	Recruiting
Odense University Hospital	Odense	Denmark	Recruiting
Helsinki University Central Hospital	Helsinki	Finland	Recruiting
Kuopio University Hospital	Kuopio	Finland	Not Yet Recruiting
Oulu University Hospital	Oulu	Finland	Not Yet Recruiting
Tampere University Hospital	Tampere	Finland	Not Yet Recruiting
Turku University Hospital	Turku	Finland	Not Yet Recruiting
University of Leipzig Medical Center	Leipzig	Germany	Recruiting
Universitätsklinikum Tübingen	Tübingen	Germany	Recruiting
Semmelweis University, 2nd Dept of Pediatrics	Budapest	Hungary	Recruiting
Ospedale Pediatrico Bambino Gesù	Rome	Rome	Recruiting
Hospital of Lithuanian University of Health Sciences Kauno klinikos	Kaunas	Lithuania	Recruiting
Radboud University Nijmegen Medical Centre	Nijmegen	Gelderland	Recruiting
UMC Groningen	Groningen	Netherlands	Active Not Recruiting
UMC Utrecht	Utrecht	Netherlands	Recruiting
Haukeland University Hospital	Bergen	Norway	Recruiting
Oslo University Hospital	Oslo	Norway	Not Yet Recruiting
University Hospital of North Norway	Tromsø	Norway	Not Yet Recruiting
St. Olav's Hospital	Trondheim	Norway	Recruiting
Sant Joan de Déu Barcelona Hospital	Barcelona	Spain	Recruiting
Sahlgrenska University Hospital	Gothenburg	Sweden	Recruiting
Linköping University Hospital	Linköping	Sweden	Recruiting
Skåne University Hospital	Skåne	Sweden	Recruiting
Karolinska University Hospital	Stockholm	Sweden	Recruiting
University Hospital of Umeå	Umeå	Sweden	Recruiting
Uppsala University Hospital	Uppsala	Sweden	Recruiting
Alder Hey Childrens NHS Foundation Trust	Liverpool	United Kingdom	Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT02300766 on ClinicalTrials.gov ↗ ← All trials in Germany