Dexmedetomidine Versus Lidocaine for Optic Nerve Sheath Diameter During Craniotomy Intubation

NCT07820540 · tracked via the Priya Life Science Egypt tracker

Sponsor

Benha University

Phase

Phase 4

Started

2026-09-20

Last updated

2026-09-15

Condition(s) studied

Endotracheal Intubation

Investigational drug(s) / intervention(s)

Dexmedetomidine →Lidocaine →Normal Saline

Dexmedetomidine: Dexmedetomidine will be administered intravenously at a dose of 1 microgram per kilogram over 10 minutes before induction of general anesthesia.

Lidocaine: Lidocaine will be administered intravenously at a dose of 1.5 milligrams per kilogram as a slow bolus 2-3 minutes before induction of general anesthesia.

Normal Saline: Normal saline will be administered intravenously as placebo before induction of general anesthesia in a manner intended to maintain study blinding.

Study summary

Endotracheal intubation during general anesthesia can cause temporary increases in heart rate, blood pressure, and intracranial pressure. These changes may be particularly important in patients undergoing craniotomy. Optic nerve sheath diameter, measured noninvasively using ultrasound, can be used as an indirect marker of changes in intracranial pressure.

This randomized controlled trial will compare intravenous dexmedetomidine, intravenous lidocaine, and normal saline in patients undergoing elective supratentorial craniotomy under general anesthesia. The study will evaluate whether dexmedetomidine or lidocaine can reduce changes in optic nerve sheath diameter associated with endotracheal intubation and improve hemodynamic stability compared with placebo.

The investigators hypothesize that dexmedetomidine and lidocaine will attenuate the increase in optic nerve sheath diameter and the hemodynamic response associated with endotracheal intubation.

Eligibility

Sex

ALL

Min age

18 Years

Max age

65 Years

Healthy volunteers

Inclusion Criteria: * Adults aged 18 to 65 years * Male or female participants * American Society of Anesthesiologists physical status I to III * Scheduled for elective supratentorial craniotomy under general anesthesia Exclusion Criteria: * Raised intraocular pressure * Pre-existing eye disease or ocular injury * Severe cardiac or pulmonary disease * Hepatic or renal impairment * Coagulopathy * Pregnancy * Known allergy to any of the study drugs * Difficult airway * Emergency craniotomy

Primary outcome measure(s)

Optic Nerve Sheath Diameter — Perioperative: baseline before induction; immediately after induction before laryngoscopy; immediately after intubation; 5 and 10 minutes after intubation.
Optic nerve sheath diameter will be measured in millimeters using ultrasonography with a high-frequency linear probe placed gently over the closed upper eyelid. The measurement will be obtained 3 millimeters posterior to the globe.

Trial sites (1)

Facility	City	Region	Status
Benha University Hospitals	Banhā	Qalyubia Governorate

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07820540 on ClinicalTrials.gov ↗ ← All trials in Egypt