Magnesium sulfate (MgSO4): After the induction of anesthesia, the patients will receive loading intravenous magnesium sulfate (50mg/kg over 20 minutes) and maintenance (15mg/kg/hr) till the end of surgery.
Normal Saline: The patients will receive the same normal saline volume for loading and maintenance.
Study summary
The aim of this study is to detect the effect of intraoperative intravenous magnesium sulfate on postoperative systemic inflammatory response by serum inflammatory parameters as CRP, WBCS and neutrophil count.
Eligibility
Sex
ALL
Min age
35 Years
Max age
75 Years
Healthy volunteers
No
Inclusion Criteria:
* ASA I and ASA II.
* Age (35yrs - 75yrs).
* Patients undergoing open colorectal cancer surgery.
* Sex: Both sexes.
Exclusion Criteria:
* Renal impairment (Glomerular Filtration Rate \< 60 ml\\min).
* Severe cardiac dysfunction (Ejection fraction ≤ 30% or clinical signs and symptoms of reduced left ventricular ejection fraction), preoperative bradycardia (HR \< 50 bpm) and atrioventricular block (first, second and third degree).
* Allergy to study drug (MgSO4).
* Patient refusal to precipitate in this study.
* Autoimmune disorders (eg: rheumatoid arthritis, multiple sclerosis and lupus), congenital and acquired immunodeficiency.
* Previous / current immunomodulatory therapy.
* Emergency condition (eg: obstruction or perforation in colorectal cancer).
* Postoperative complications altering inflammatory response (eg: infection, anastomotic leak).
* Duration of operation \> 5 hours.
* Cognitive impairment (eg: Dementia) and other psychiatric disorders by history.
* Body mass index less than 18 or greater than 30 kg/m².
Primary outcome measure(s)
postoperative white blood cell count (WBC) — inflammatory markers will be measured at 2 time points: 12 and 36 hours after surgery. Assess effect of intravenous magnesium sulfate on postoperative inflammation by serum inflammatory marker as WBCS.
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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