Effect of Theravex Tissue Care on Implant Stability

NCT07707388 · tracked via the Priya Life Science Egypt tracker

Sponsor

Ain Shams University

Phase

Not applicable

Started

2026-11-12

Last updated

2026-07-16

Condition(s) studied

Immediate Dental Implant Placement

Investigational drug(s) / intervention(s)

Bone Bioactive LiquidBovine-derived XenograftImmediate Implant Placement

Bone Bioactive Liquid: A bone bioactive liquid (Theravex) applied directly into the jumping gap and on implant surface immediately following implant placement to stimulate early bone healing and osseointegration.

Bovine-derived Xenograft: Bovine derived- xenograft will be packed into the jumping gap to maintain volume and provide an osteoconductive scaffold for bone formation.

Immediate Implant Placement: Surgical placement of the dental implant into the fresh extraction socket immediately following tooth extraction, according to standard surgical protocols.

Study summary

The aim of this randomized clinical trial is to evaluate the clinical and radiographic outcomes of using Bone Bioactive Liquid (Theravex) compared to Xenograft and a combination therapy (Theravex + Xenograft) during immediate implant placement in the esthetic zone.

When a tooth is extracted and replaced immediately with a dental implant, bone grafting is often necessary to fill the gap (jumping distance) between the implant and the surrounding bone socket to support tissue healing and maintain facial contour.

Participants requiring immediate implant placement will be randomly assigned into three groups:

Group 1: Immediate implant placement using Bone Bioactive Liquid (Theravex).

Group 2: Immediate implant placement using Xenograft alone.

Group 3: Immediate implant placement using Combination Therapy (Theravex + Xenograft).

The primary outcomes will evaluate implant stability, bone dimensional changes, and soft tissue response around the implants over the follow-up period.

Eligibility

Sex

ALL

Min age

—

Max age

—

Healthy volunteers

Accepted

Inclusion Criteria: * Patient requires extraction of a single failing or non-restorable maxillary anterior tooth or premolar. * Presence of an intact buccal bone plate (Socket Type I) with a horizontal peri-implant jumping gap ≥ 2 mm. * The implant can be placed in an ideal 3-D position with an intraoperative primary stability target of ≥ 35 Ncm. * Patient is in good general health with no systemic contraindications to implant surgery. * Patient is cooperative and available for the entire 6-month follow-up period Exclusion Criteria: * Pregnant and lactating females. * Heavy smokers (smoking ≥ 10 cigarettes per day). * Patients with poor oral hygiene. * Patients with occlusal or malalignment problems. * Patients with parafunctional habits (e.g., bruxism).

Primary outcome measure(s)

Implant Stability Quotient (ISQ) — Baseline (during surgery), 4 weeks, 3 months, and 6 months post-operatively.
Implant stability will be measured using Resonance Frequency Analysis (RFA) to record the Implant Stability Quotient (ISQ) values.

Trial sites (1)

Facility	City	Region	Status
Faculty of Dentistry - Ain Shams University	Cairo	Egypt

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07707388 on ClinicalTrials.gov ↗ ← All trials in Egypt