This prospective observational cohort study aims to compare the predictive accuracy of diaphragmatic rapid shallow breathing index (D-RSBI) versus traditional rapid shallow breathing index (RSBI) for predicting weaning success from invasive mechanical ventilation in COPD patients. Diaphragmatic ultrasound measurements will be performed during spontaneous breathing trials, and patients will be followed for 72 hours after extubation to assess weaning outcomes.
Eligibility
Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria:
* Mechanically ventilated COPD patients fulfilling standard weaning readiness criteria.
* Invasive mechanical ventilation for more than 24 hours before spontaneous breathing trial.
* Hemodynamically stable without significant vasopressor support.
* Adequate oxygenation with FiO2 ≤ 0.5 and PEEP ≤ 8 cmH2O .
* Preserved mental status and ability to initiate spontaneous breathing.
* Successful tolerance of spontaneous breathing trial conducted on CPAP mode with pressure support ≤ 8 cmH2O.
Exclusion Criteria:
* Refusal of consent
* Neuromuscular disease, phrenic nerve palsy, or diaphragmatic paralysis.
* Large pneumothorax or pathology interfering with ultrasound assessment.
* Terminal extubation.
* Recent major thoracic surgery.
* Poor sonographic window despite repeated attempts.
Primary outcome measure(s)
AUROC of D-RSBI for prediction of successful weaning — Within 72 hours after extubation Area under the receiver operating characteristic curve (AUROC) of diaphragmatic rapid shallow breathing index (D-RSBI) for predicting successful weaning within 72 hours after extubation in mechanically ventilated COPD patients.
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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