Rutin + Vitamin C: Type: Drug (Combination therapy) Details: Oral administration of two tablets containing 60 mg Rutin + 160 mg Vitamin C, taken three times daily for 12 weeks.
Vitamin C 500mg: Type: Drug (Single agent) Oral administration of Vitamin C 500 mg, taken twice daily for 12 weeks
Lifestyle Intervention: Mediterranean diet focusing on fruits, vegetables, whole grains, healthy fats, plus structured exercise program for 12 weeks.
Study summary
evaluate the combined effects of Rutin and Vitamin C versus Vitamin C alone on selected oxidative stress markers, inflammation, hepatic steatosis regression, and associated metabolic parameters in patients with MASLD
Eligibility
Sex
ALL
Min age
18 Years
Max age
65 Years
Healthy volunteers
No
Inclusion Criteria:
* Confirmed diagnosis of Metabolic-Associated Steatotic Liver Disease (MASLD).
Exclusion Criteria:
* HCV infection.
* HBV infection.
* Patients with a history of significant alcohol consumption.
* Autoimmune hepatitis.
* Celiac disease (CD).
* Wilson's disease (WD).
* Haemochromatosis.
* Drugs: Tamoxifen, Valproic acid, Amiodarone, Methotrexate, steroids and immunosuppressive agents, oral contraceptive pills, or drugs that can affect liver profile.
* Hypo or hyper thyroidism.
* Bypass surgeries.
* TPN (Total Parenteral Nutrition).
* Pregnant individuals or patients planning to become pregnant.
Primary outcome measure(s)
• Change in tumor necrosis factor-alpha (TNF-α) levels from baseline to week 12. — 12 weeks Serum TNF-α, a key biomarker of inflammation in MASLD
Trial sites (1)
Facility
City
Region
Status
National Hepatology and Tropical Medicine Research Institute (NHTMRI)
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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