Intrathecal Dexmedetomidine-Fentanyl Combination Versus Fentanyl Alone as Adjuvant to Bupivacaine in Spinal Anesthesia for Above Knee Amputation in Sarcomas of Lower Extremity
Fentanyl + Dexmedetomidine: Patients will receive 2.5 mL of 0.5% hyperbaric bupivacaine with 25 µg fentanyl + 5 µg dexmedetomidine.
Fentanyl: Patients will receive 2.5 mL of 0.5% hyperbaric bupivacaine with 25 µg fentanyl.
Study summary
The current work evaluated whether the combination of intrathecal dexmedetomidine and fentanyl provides superior postoperative analgesia to fentanyl alone when administered with hyperbaric bupivacaine.
Eligibility
Sex
ALL
Min age
18 Years
Max age
60 Years
Healthy volunteers
No
Inclusion Criteria:
* Age from 18 to 60 years.
* Both sexes.
* American Society of Anesthesiologists (ASA) physical status of II-III.
* Height between 150-185 cm.
* Body mass index between 18-35 kg/m².
* Scheduled for above-knee amputation due to lower limb sarcomas.
Exclusion Criteria:
* Allergy to any of the investigated drugs.
* History of heart block, arrhythmia, or ongoing therapy with beta- or calcium channel- blockers, or angiotensin-converting-enzyme inhibitors.
* Contraindications to spinal anesthesia.
* Pregnancy or lactation.
* Presence of psychiatric illness or chronic pain conditions.
Primary outcome measure(s)
Time to first rescue analgesia — 24 hours postoperatively Time to first rescue analgesia (time from the end of surgery till the first dose of morphine is administered).
Trial sites (1)
Facility
City
Region
Status
National Cancer Institute
Cairo
Egypt
Recruiting
More National Cancer Institute, Egypt trials in Egypt
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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