Comparative Study Evaluating Safety and Effectiveness of ( Proton Pump Inhibitor Versus Vonoprazan ) Based Triple Therapy With or Without Zinc to Eradicate H. Pylori Infection
zinc sulfate: Effect of using Zinc in Helicobacter pylori Treatment
Vonoprazan + amoxicillin + clarithromycin: Effect of using Vonoprazan + amoxicillin + clarithromycin in Helicobacter pylori Treatment
proton pump inhibitor + amoxicillin: Effect of using proton pump inhibitor + amoxicillin in Helicobacter pylori Treatment
Study summary
this Study Evaluating Safety and Effectiveness of (Proton Pump Inhibitor versus Vonoprazan) Based Triple Therapy with or without Zinc to Eradicate H. pylori Infection
Eligibility
Sex
ALL
Min age
19 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria:
* Age \> 18.
* Both males and females.
* Patients who are positive for H.pylori infection by non-invasive Stool Antigen Test (SAT).
Exclusion Criteria:
* Prior H. pylori treatment: Previous treatment for H. pylori infection.
* Allergies: Known allergies to study medications or components.
* Patients cannot finish treatment course.
* Pregnant and Lactating Women.
* Patients with Kidney disease and eGFR \< 30ml/min.
* Patients with Liver disease with Child-Pugh B or C.
Primary outcome measure(s)
Serum interleukin-6 (IL-6) level: will be assessed by ELISA — 8 weeks \- Blood samples: collected from all participants at base line before PPI based triple therapy (Omeprazole /pantoprazole 40mg with amoxicillin 1000mg and clarithromycin 500mg twice daily), 220mg Zinc Sulphate which is equivalent to 50mg elemental zinc and P-CABs based triple therapy (Vonoprazan 20 mg and amoxicillin 1000mg plus clarithromycin 500 mg twice daily) , and then 4 weeks after finishing the treatment from each group for the assessment of the f by Serum interleukin-6 (IL-6) level: will be assessed by ELISA.
H. pylori stool antigen test (SAT) — 8 weeks \- H. pylori stool antigen test (SAT): test at base line for diagnosis and then 4 weeks after finishing the treatment
Serum Pepsinogen level: will be assessed by ELISA. — 8 weeks Blood samples: collected from all participants at base line before PPI based triple therapy (Omeprazole /pantoprazole 40mg with amoxicillin 1000mg and clarithromycin 500mg twice daily), 220mg Zinc Sulphate which is equivalent to 50mg elemental zinc and P-CABs based triple therapy (Vonoprazan 20 mg and amoxicillin 1000mg plus clarithromycin 500 mg twice daily) , and then 4 weeks after finishing the treatment from each group for the assessment of the f by Serum Pepsinogen level: will be assessed by ELISA.
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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