Dexamethasone Versus Magnesium Sulphate as an Adjuvant to Bupivacaine in Ultrasound Guided Erector Spinae Plane Block for Postoperative Analgesia in Elective Caesarean Section Under Spinal Anesthesia
Bupivacaine: Patients will receive 20 ml of 0.25% isobaric bupivacaine.
Dexamethasone: Patients will receive 20 ml of (0.25% isobaric bupivacaine and 4mg of dexamethasone).
Magnesium sulphate: Patients will receive 20 ml of (0.25% isobaric bupivacaine and 200mg of magnesium sulphate).
Study summary
This study aims to compare the efficacy of adding dexamethasone and magnesium sulfate as an adjuvant to bupivacaine in bilateral erector spinae block in postoperative pain control in patients undergoing caesarean section under spinal anesthesia.
Eligibility
Sex
ALL
Min age
18 Years
Max age
35 Years
Healthy volunteers
No
Inclusion Criteria:
* Age from 18 to 35 years.
* Full-term, singleton, pregnant women.
* American Society of Anesthesiologists (ASA) physical status II.
* Scheduled for elective cesarean delivery under spinal anesthesia.
Exclusion Criteria:
* Refusal of the patient.
* Emergency caesarean sections.
* Patients having chronic diseases as asthma, cardiovascular disorders (Significant arrhythmias, Severe Valvular diseases, congenital heart diseases, ischemic heart disease, cardiomyopathy, deep venous thrombosis ,and pulmonary embolism)
* Renal impairment (Creatinine level ≥ 2mg/dl, urea ≥ 25mg/dL), liver impairment \[Alanine aminotransferase (ALT) \< 45 U/L, Aspartate aminotransferase (AST) \< 45 U/L\].
* Allergy to the drug enrolled in the study.
* Body mass index (BMI) ≥ 35 kg/m2.
* Hypertensive disorders of pregnancy.
* Contraindication to spinal anesthesia, such as coagulopathy \[platelet count \<150.000, international normalized ratio (INR) \> 1.2\], or local infection.
* Requirement for conversion to general anesthesia after spinal anesthesia will also be excluded.
Primary outcome measure(s)
Time to first analgesic requirement — 24 hours postoperatively Time to first analgesic requirement in the following 24 hours after cesarean delivery. It is the time elapsed between performing the assigned intervention and first morphine requirement.
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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