Conventional double antibiotic paste of Metronidazole 500 mg plus Ciprofloxacin 500 mg mixed with propylene glycolDouble antibiotic paste of Metronidazole and Ciprofloxacin loaded chitosan-coated silver nanoparticleschitosan-coated silver nanoparticles
Conventional double antibiotic paste of Metronidazole 500 mg plus Ciprofloxacin 500 mg mixed with propylene glycol: The studied medicament will be placed onto the floor of the pulp chamber.
Double antibiotic paste of Metronidazole and Ciprofloxacin loaded chitosan-coated silver nanoparticles: The studied medicament will be placed onto the floor of the pulp chamber.
chitosan-coated silver nanoparticles: The studied medicament will be placed onto the floor of the pulp chamber.
Study summary
Management of non-vital primary molars is challenging due to the natural anatomy of primary teeth, patients' young age, and their behavior toward dental treatment. A simple and effective technique such as Lesion Sterilization and Tissue Repair offers a solution to cases with poor prognosis; however, the medicaments used in this technique have some limitations. This study will evaluate three different medicaments regarding the clinical success, radiographic success, and antibacterial activity.
Eligibility
Sex
ALL
Min age
4 Years
Max age
8 Years
Healthy volunteers
Accepted
Inclusion Criteria:
* Healthy cooperative children of both sexes in the age range of 4-8 years old.
* Children with consenting parents who accept to participate in the study and sign the consent forms.
* Children with mandibular primary molars with clinical and radiographic signs of pulpal necrosis.
Exclusion Criteria:
* Children with hypersensitivity to any of the used medicaments.
* Non-restorable teeth without sufficient coronal structure for placement of rubber dam isolation and restoration with stainless steel crowns
* Non-restorable teeth with perforated pulpal floor
Primary outcome measure(s)
Clinical success — 1,6, and 12 months follow up 1. Absence/decrease of pain related to the treated teeth including patient reported pain or sensitivity to palpation/percussion
2. Absence/decrease of gingival swelling related to the treated teeth
3. Absence/decrease of pathological mobility related to the treated teeth
Radiographic success — 6 and 12 months follow up 1. Absence/decrease/stasis of furcation radiolucency related to the treated teeth
2. Absence/stasis of pathological root resorption of the treated teeth
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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