Menaquinone: the socket will be filled with crushed capsule of vitamin k2 menaquinone in study group
Study summary
This study is a randomized controlled trial comparing the effects of socket grafting with crushed vitamin K2 (menaquinone)capsules versus no grafting on bone density and socket dimensions following tooth extraction. Patients are randomly assigned to one of two groups:
Study Group (Group I): Patients receive socket grafting with crushed vitamin K2 (menaquinone) capsules. The socket is covered with an absorbent sponge, and non-resorbable sutures are placed to stabilize the graft material and achieve soft tissue stability.
Control Group (Group II): Patients undergo socket healing without grafting. The socket is covered with an absorbent sponge, and non-resorbable sutures are placed over it.
Outcome measures include bone socket dimensions evaluated immediately after extraction with graft material, as well as assessment after 4 months using cone beam computed tomography (CBCT) radiographs. Additionally, core biopsies are taken at the time of implant placement.
Eligibility
Sex
ALL
Min age
18 Years
Max age
80 Years
Healthy volunteers
Accepted
Inclusion Criteria:• Age \> 18 years without other age or gender restrictions.
* Patients requiring extraction of mandibular single-rooted teeth.
Exclusion Criteria:
* • Patients with systemic conditions affecting bone metabolism.
* Allergies or sensitivities to hydroxyapatite or Vitamin K2
* Untreated or residual periodontal disease;
* Uncontrolled diabetes (HbA1c \> 7.5%);
* Head and/or neck radiotherapy
* Immunosuppressive therapy
* Pregnant or nursing
* Substance abuse
* Treated or under treatment with intravenous amino-bisphosphonates
* Patients participating in other studies, if the present protocol could not be properly followed.
Primary outcome measure(s)
Marginal bone loss — baseline and 4 month after extraction At the time of extraction, CBCT imaging will provide baseline data on the initial bone structure This baseline measurement serves as a reference point for evaluating any subsequent changes in bone density and morphology.
After four months, another CBCT scan will be conducted to assess the amount of marginal bone loss that has occurred since the initial extraction. By comparing the post-extraction CBCT images with those taken after four months, researchers can quantify any changes in bone volume and identify any areas of concern related to bone resorption. The unit of measurement for the primary outcome, vertical bone change (socket height), is millimeters (mm).
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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