Obesity &Amp; OverweightObesity Type 2 Diabetes MellitusType 2 Diabetes (T2DM)PrediabetesInflammationAdipose TissueAdipose Tissue Inflammation
Study summary
In this study, the objective is to investigate inflammation in the arteries of the heart. A heart CT scan (CCTA) will be used to measure inflammation by assessing the fat tissue surrounding the arteries of the heart. Participants with and without type 2 diabetes who have no heart symptoms have been examined and had a CCTA scan performed.
This study aims to answer the following questions:
• Is inflammation in the surrounding fat tissue of the heart arteries associated with the following glycometabolic conditions: I) Obesity ii) Prediabetes iii) Type 2 diabetes
Eligibility
Sex
MALE
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria:
* Above 18 years
* Capable of giving written informed consent
Exclusion Criteria:
* History of CAD
* Symtoms of CAD (angina)
* Any tachyarrhythmias making CCTA impossible
* Estimated glomerular filtration rate (eGFR) under 45 ml/min
* Allergy to iodine contrast
* Critical illness with life expectancy less than 1 year
* Documented heart failure
Primary outcome measure(s)
PCAT Attenuation [Hounsfield Units (HU)] measured by coronary CT angiography — Baseline PCAT attenuation \[HU\] will be assessed for correlation with the following variables:
* BMI \[kg/m²\] \[Continously, and categorized as normal (ref), overweight, obesity class 1, obesity class 2+\].
* Prediabetes, defined as HbA1c: 39-47 mmol/mol \[Categorical: no(ref)/yes\].
* Type 2 diabetes mellitus, defined by WHO criteria \[Categorical: no(ref)/yes\].
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
We use cookies to analyse site traffic and improve your experience. With your consent, we may also use cookies for advertising. You can change your choice at any time.