1. To describe the bone morphology in patients with reduced renal function and high or low parathyroid hormone (PTH) respectively.
2. To investigate if the non-invasive method 18-Fluoride Positron Emission Tomography (18F-PET) can describe the bone turnover and reflect the bone histomorphologic changes
3. To investigate if non-oxidized PTH reflects bone turnover
Eligibility
Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Patients with reduced renal function:
Inclusion Criteria:
-≥ 18 years
* estimated Glomerular Filtration Rate (eGFR) ≤ 20 ml/min/1,73m2
* PTH \< 150 pg/ml or PTH \> 300 pg/ml
Exclusion Criteria:
* ongoing malignancy
* Allergy towards tetracyclin
* Pregnancy
Control Group:
Inclusion Criteria:
-≥ 18 years
* eGFR \>= 60 ml/min
* under examination for c prostata
* Prostatic Specific Antigen (PSA) total \<40 µg/l
Exclusion:
* Former kidney disease
* ionized calcium or PTH outside normal range
* Known metabolic bone disease
* treatment with anticoagulants
* Disturbed thrombosis and hemostasis
Primary outcome measure(s)
Can 18F-PET-CT describe bone formation rate? — The bone biopsy and 18F-PET will be performed during two month for each participant The ROC curve for 18F uptake by bone measured as bone plasma clearance (ki) to descriminate between high and low bone turnover measured as bone formation rate
Can non-oxidized PTH describe bone formation rate? — Blood sample and bone biopsy will be performed during two month for each participant The relation between non-oxidized PTH in ng/L and bone turnover in bone biopsy described as bone formation rate
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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