Small RNA tRF-31 Changes in Patients With Age-Related Cataract

NCT07672899 · tracked via the Priya Life Science China tracker

Sponsor

Second Affiliated Hospital, Zhejiang University, School of Medicine

Phase

Observational

Started

2026-06-17

Last updated

2026-06-29

Condition(s) studied

Cataract

Investigational drug(s) / intervention(s)

Biospecimen collection (Anterior lens capsule)

Biospecimen collection (Anterior lens capsule): This is an observational study without investigational interventions. Participants will undergo standard-of-care phacoemulsification combined with intraocular lens implantation for age-related cataract. During the routine continuous curvilinear capsulorhexis (CCC) step of the surgery, the central anterior lens capsule, which is typically discarded as medical waste, will be collected for subsequent molecular analysis. This tissue collection relies entirely on the standard surgical procedure and does not alter the patient's routine clinical treatment pathway in any way.

Study summary

The goal of this observational study is to evaluate the expression characteristics and clinical relevance of the tRF-31/HIPK2 signaling axis in adults over 18 years old with age-related cataract (ARC). The main questions it aims to answer are: Is there a correlation between the relative expression levels of tRF-31 and its target gene HIPK2 in the anterior lens capsule and the clinical severity (Emery-Little grading system) of age-related cataracts? Does oxidative stress in the anterior segment microenvironment have a potential bystander effect on the state of the corneal endothelium? Participants will:Undergo routine preoperative ophthalmologic examinations, including visual acuity tests, slit-lamp photography, and corneal endothelial cell counting. Undergo standard cataract surgery (phacoemulsification combined with intraocular lens implantation) as part of their regular medical care. Allow researchers to collect and analyze their anterior lens capsule tissue, which is routinely removed and typically discarded as medical waste during the standard continuous curvilinear capsulorhexis (CCC) step of the surgery.

Eligibility

Sex

ALL

Min age

18 Years

Max age

—

Healthy volunteers

Inclusion Criteria: Patients older than 18 years. Clinically diagnosed with age-related cataract (ARC) and have clear surgical indications for routine phacoemulsification combined with intraocular lens (IOL) implantation. Scheduled to undergo cataract extraction and intraocular lens implantation. Completed routine preoperative corneal endothelial specular microscopy, providing objective data including cell density, coefficient of variation of cell area, and the proportion of hexagonal cells. Provided signed written informed consent. Exclusion Criteria: History of ocular trauma, glaucoma, episodes of active uveitis, or previous intraocular surgery. Presence of severe systemic diseases rendering the patient unsuitable for surgery. Poor patient compliance or coexisting psychiatric disorders. Severe systemic metabolic syndromes (e.g., diabetes). Diagnosis of high myopia. Current participation in other clinical trials or likelihood of being lost to follow-up.

Primary outcome measure(s)

Correlation between relative expression of tRF-31 and cataract nuclear hardness (Emery-Little grading system) — Baseline (Preoperative, up to 1 month prior to surgery)

Trial sites (1)

Facility	City	Region	Status
Second Affiliated Hospital of Zhejiang University School of Medicine	Hangzhou	Zhejiang	Recruiting

More Second Affiliated Hospital, Zhejiang University, School of Medicine trials in China

Microneedle Intra-Arterial Injection for Retinal Artery Occlusion Recruiting

Guselkumab Vs Ustekinumab in Stricturing Crohn's Disease Recruiting

Multicenter Study on the Use of Intraoperative OCT in the Diagnosis and Management of Lens Diseases Active, not recruiting

China Longitudinal Aging and Cognitive Impairment Study Recruiting

Effect of Incentive Integrated E-IBD Chronic Disease Management Model on the Quality of Life in IBD Patients Starting soon

Other trials for the same condition

Multicenter Study on the Use of Intraoperative OCT in the Diagnosis and Management of Lens Diseases Active, not recruiting

Visual Quality of Cataract Patients with High Myopia After Implantation of Different Intraocular Lenses Active, not recruiting

Postoperative Rotational Dynamics of Three Toric Intraocular Lens Designs Recruiting

Comparison of Early Postoperative Visual Acuity Between Intracapsular and Supracapsular Phacoemulsification: A Randomized Controlled Clinical Trial Starting soon

D615L vs Zeiss 839MP: Visual Quality Active, not recruiting

Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07672899 on ClinicalTrials.gov ↗ ← All trials in China