The Effect of Oral Oxytocin and Atosiban on Social Attention

Condition(s) studied

Investigational drug(s) / intervention(s)

Oxytocin lower dose (24IU): Oxytocin (24IU) will be administered as a lingual spray (6, 0.1 puffs (4IU per puff) of spray on and under the tongue)

Oxytocin higher dose (48IU): 48IU oxytocin administered as a lingual spray (6, 0.1ml sprays (8IU per puff) on or under the tongue)

Atosiban: 150ug atosiban administered by lingual sprays (6, 0.1ml sprays on and under the tongue)

Placebo: Placebo administered as a lingual spray (6, 0.1 ml sprays one and under the tongue. Placebo has the same composition of 0.9% saline and glycerol as for oxytocin and atosiban interventions

Study summary

The main aim of the present study is to investigate whether orally (lingual spray) administered oxytocin influences human social attention and behaviors via oxytocin receptors and whether its effects are dose- and task-dependent.

Eligibility

Primary outcome measure(s)

• Fixation duration — Fixation durations will be taken for each of the areas of interest in the four different visual paradigms starting 45 minutes post-treatment from the beginning of each paradigm until the end of each paradigm (each paradigm lasts around 10 minutes)
  Fixation time on different areas of interest in the different visual presentation paradigms using eye-tracking
• Fixation counts — Fixation counts will be taken for each of the areas of interest in the four different visual paradigms starting 45 minutes post-treatment, from the beginning of each paradigm until the end of each paradigm (each paradigm lasts around 10 minutes).
  Total number of fixations made by participant towards the different areas of interest in the different visual paradigms using eye-tracking

Trial sites (1)

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