Oxytocin and Human Defensive Responses in a Dynamic Situation

Condition(s) studied

Investigational drug(s) / intervention(s)

Oxytocin nasal spray: intranasal administration of oxytocin (24 IU)

Placebo: intranasal administration of placebo (24 IU)

Study summary

The presnet study is to investigate the effect of intranasal oxytocin (24 IU) treatment on modulating how human responsd to threat in a dynamic situation.

Eligibility

Primary outcome measure(s)

• Escape sucess rates when confronting different predators — 1 hour
  Escape sucess rates in successfully entering the refuge when confronting the fast, medium and slow predators.
• Flight initiation distance — 1 hour
  It is the prey-predator distance when a prey flees from a threat, a key index quantifying escape decisions.
• The distance to refuge — 1 hour
  The distance to refuge when a prey flees from a threat.
• Brain activity patterns in response to threats along the predatory imminence continuum — 1 hour
  Brain activity patterns in response to different predators along the predatory imminence continuum. We will examine these brain response patterns via both the conventional univariate analysis and the machine learning-based multivariate pattern analysis (MVPA) approaches. Based on previous studies, the medium predator is a priori used as an anchor for fast and slow predators for a more sensitive measure of brain activity differences and contrasts with the medium predator would be reported in the suplemental files for completeness (if there were significant effects).

Trial sites (1)

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