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Clinical Trials in China / NCT06840002
Recruiting Phase 1/2

A Clinical Study of SHR-A1811 Combined With Chemotherapy for Platinum Sensitive Recurrent Ovarian Cancer

NCT06840002 · tracked via the Priya Life Science China tracker
Sponsor
Suzhou Suncadia Biopharmaceuticals Co., Ltd.
Phase
Phase 1/2
Started
2025-03-18
Last updated
2026-09-11

Condition(s) studied

Ovarian Cancer

Investigational drug(s) / intervention(s)

SHR-A1811 →Carboplatin →Bevacizumab →Oxaliplatin for Injection →Paclitaxel injection →Doxorubicin hydrochloride liposome injection →Adebrelimab Injection →

SHR-A1811: SHR-A1811.

Carboplatin: Carboplatin.

Bevacizumab: Bevacizumab.

Oxaliplatin for Injection: Oxaliplatin for injection.

Paclitaxel injection: Paclitaxel injection.

Doxorubicin hydrochloride liposome injection: Doxorubicin hydrochloride liposome injection.

Adebrelimab Injection: Adebrelimab injection.

Study summary

The objective is to evaluate the tolerance, safety, pharmacokinetic characteristics and immunogenicity of SHR-A1811 combined with carboplatin and bevacizumab in the treatment of platinum sensitive recurrent epithelial ovarian cancer, and to determine the RP2D of the combination, and preliminarily to evaluate the effectiveness of SHR-A1811 combined regimen in the treatment of platinum sensitive recurrent epithelial ovarian cancer.

Eligibility

Sex
FEMALE
Min age
18 Years
Max age
75 Years
Healthy volunteers
No
Inclusion Criteria: 1. Voluntarily join this study, sign the informed consent form, have good compliance, and can cooperate with the follow-up. 2. Sufficient fresh or archived tumor tissue specimens can be provided for testing by the third-party central laboratory designated by the sponsor. 3. At least one measurable lesion conforming to RECIST v1.1. 4. ECOG PS score: 0-1. 5. Expected survival ≥ 12 weeks. 6. Female subjects with fertility must agree to comply with the contraceptive requirements from signing the informed consent form to 7 months after the last administration of the trial drug. Exclusion Criteria: 1. With untreated or active central nervous system (CNS) tumor metastasis. Subjects with a history of meningeal metastasis or current meningeal metastasis. 2. Pleural effusion, pericardial effusion or peritoneal effusion with clinical symptoms, which cannot be well controlled. 3. Previous interstitial pneumonia or interstitial lung disease, non infectious pneumonia requiring steroid treatment. 4. With hypertension and cannot be well controlled by antihypertensive drug treatment. 5. Accompanied by poorly controlled or serious cardiovascular diseases. 6. Subjects with serious infection within 1 month before the first medication. 7. Have a history of immune deficiency, including HIV test positive, other acquired or congenital immune deficiency diseases, or a history of organ transplantation. 8. There are any other factors that may affect the results of the study or cause the forced termination of the study, such as alcohol abuse, drug abuse, criminal detention, and other serious diseases (including mental illness) that need combined treatment.

Primary outcome measure(s)

Trial sites (1)

FacilityCityRegionStatus
Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology Wuhan Hubei Recruiting

On this site

📄 Avastin (bevacizumab) drug profile →

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06840002 on ClinicalTrials.gov ↗ ← All trials in China