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Clinical Trials in China / NCT03519230
Active, not recruiting Phase 3

Maintenance Treatment With BGB-290 Versus Placebo in Participants With Platinum-sensitive Recurrent Ovarian Cancer

NCT03519230 · tracked via the Priya Life Science China tracker
Sponsor
BeiGene
Phase
Phase 3
Started
2018-05-14
Last updated
2026-03-16

Condition(s) studied

Ovarian Cancer

Investigational drug(s) / intervention(s)

Pamiparib capsulePlacebo capsule

Pamiparib capsule: 60 mg twice daily (BID), orally (per os-PO)

Placebo capsule: 60mg BID, PO

Study summary

To evaluate the efficacy, safety and tolerability of maintenance therapy with BGB-290(Pamiparib) versus placebo in Chinese participants with recurrent ovarian cancer who achieved a complete response (CR) or partial response (PR) after platinum-based chemotherapy

Eligibility

Sex
FEMALE
Min age
18 Years
Max age
Healthy volunteers
No
Key Inclusion Criteria: 1. Histologically diagnosed high-grade serous or endometrioid ovarian cancer (including primary peritoneal and fallopian tube cancer) 2. Completion of ≥2 previous platinum-containing regimens (eg, carboplatin or cisplatin) 3. Complete response (CR) or partial response (PR) achieved with last platinum-based chemotherapy regimen as determined by investigator per Response Evaluation Criteria in Solid Tumors (RECIST) Version 1.1 4. Ability to be randomized ≤8 weeks after last dose of platinum Key Exclusion Criteria: 1. Prior treatment with a poly (ADP-ribose) polymerase (PARP) inhibitor 2. Progressive disease (PD) as per CA-125 criteria before randomization 3. Diagnosis of myelodysplastic syndrome (MDS) 4. Known history of intolerance to the excipients of the Pamiparib capsule NOTE: Other protocol defined Inclusion/Exclusion criteria may apply.

Primary outcome measure(s)

Trial sites (28)

FacilityCityRegionStatus
Anhui Provincial Cancer Hospital Aka West Branch of Anhui Province Hospital Hefei Anhui
Peking University First Hospital Beijing Beijing Municipality
Beijing Cancer Hospital Beijing Beijing Municipality
Peking Union Medical College Hospital Beijing Beijing Municipality
Chongqing Cancer Hospital Chongqing Chongqing Municipality
Southwest Hospital Chongqing Chongqing Municipality
Sun Yat Sen Memorial Hospital, Sun Yat Sen University (North) Guangzhou Guangdong
The First Affiliated Hospital of Guangzhou Medical University Guangzhou Guangdong
Cancer Hospital of Shantou University Medical College Shantou Guangdong
The Tumor Hospital Affiliated to Guangxi Medical University Nanning Guangxi
Harbin Medical University Cancer Hospital Harbin Heilongjiang
Henan Cancer Hospital Zhengzhou Henan
Union Hospital of Tongji Medical College, Huazhong University of Science and Technology Wuhan Hubei
Tongji Hospital of Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei
Hubei Cancer Hospital Wuhan Hubei
Hunan Cancer Hospital Changsha Hunan
Jiangxi Maternal and Child Health Hospital Nanchang Jiangxi
Jilin Cancer Hospital Changchun Jilin
The First Hospital of Jilin University Changchun Jilin
The Second Hospital of Dalian Medical University Dalian Liaoning
Liaoning Cancer Hospital and Institute Shenyang Liaoning
Qilu Hospital of Shandong University Jinan Shandong
Yantai Yuhuangding Hospital Yantai Shandong
Obstetrics and Gynecology Hospital of Fudan University Shanghai Shanghai Municipality
West China Second University Hospital Chengdu Sichuan
Tianjin Central Hospital of Gynecology Obstetrics Tianjin Tianjin Municipality
Tianjin Medical University Cancer Institute and Hospital Tianjin Tianjin Municipality
Zhejiang Cancer Hospital Hangzhou Zhejiang

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Other trials for the same condition

Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT03519230 on ClinicalTrials.gov ↗ ← All trials in China