Intradialytic Cycling: Intradialytic exercise has emerged as a safe and effective non-drug therapeutic approach to improve cardiovascular health and is now recommended for people undergoing hemodialysis treatment. Administration of a higher intensity exercise could offer better cardio-protective mechanisms and if the efficacy of cardiovascular protection is proven, it could be developed as a therapeutic option in the dialysis population.
Study summary
Patients receiving regular hemodialysis (HD) treatments are at a higher risk of cardiovascular events and death as HD can cause a decrease in the pumping of the heart during treatment called 'stunning'. Intradialytic exercise has emerged as a safe and effective non-drug approach to improve cardiovascular health and is now recommended for patients undergoing HD. It is currently advised that HD patients engage in at least 30 minutes of moderate to vigorous exercise three times per week. This study will evaluate the impact of exercise intensity in the HD population and determine if high impact exercise can offer better protection to the heart against HD-induced myocardial stunning.
Eligibility
Sex
ALL
Min age
18 Years
Max age
79 Years
Healthy volunteers
No
Inclusion Criteria:
* Must be on chronic hemodialysis for at least 3 months
* Age ≥ 18 years of age
* Willing and able to provide informed consent
Exclusion Criteria:
* Regular vigorous exercise outside hemodialysis
* \> 79 years of age
* Intradialytic exercise in the past 3 months
* Poor echogenicity
* Acute coronary syndrome in the past 3 months
* Unstable arrhythmia/angina
* Shortness of breath at rest or with minimal activity
* Symptomatic hypoglycemia (\>2x/week in the week prior to enrolment)
* Symptomatic peripheral arterial disease
* Unable or deemed unsafe to exercise for any reason
* Severe musculoskeletal or orthopedic conditions
* Aortic stenosis
* Hypertrophic cardiopathy
* Severe pulmonary hypertension
* Symptomatic hypertension
Primary outcome measure(s)
Change in the number of left ventricular segments undergoing a greater than 20% reduction in longitudinal strain as detected by echocardiogram. — Week 1 to Week 3 An echocardiogram will be completed pre-hemodialysis (HD) treatment and at peak hemodynamic stress (30 minutes before the end of HD treatment) at each of the study sessions. Images will be captured in the left lateral position and standard apical 4, and 2 chamber views will be recorded for analysis using automated speckle-training software. (EchoPac, GE Healthcare)
Trial sites (1)
Facility
City
Region
Status
London Health Sciences Centre
London
Ontario
More London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's trials in Canada
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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