Exercise Preconditioning to Protect Against Dialysis-induced Cardiac Injury

NCT06735378 · tracked via the Priya Life Science Canada tracker

Sponsor

London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's

Phase

Not applicable

Started

2025-01-20

Last updated

2025-01-22

Condition(s) studied

HemodialysisCardioprotection

Investigational drug(s) / intervention(s)

Intradialytic Cycling

Intradialytic Cycling: The impact of interdialytic exercise on cardio protection during HD has never been studied. This approach may enhance cardiovascular benefits and overall physical fitness, thereby contributing to better health outcomes in individuals undergoing HD.

Study summary

The goal of this study is to determine what happens to the heart muscle contraction when people cycle before their hemodialysis treatment. Will pre-dialysis exercise protect the heart from a decrease in pumping of the heart muscle (called stunning) that can happen during hemodialysis. We will study whether pre-dialysis exercise decreases heart stunning, decreases the number and severity of symptoms commonly associated with hemodialysis, and other outcomes

Eligibility

Sex

ALL

Min age

18 Years

Max age

79 Years

Healthy volunteers

Inclusion Criteria: * must be on chronic hemodialysis for at least 3 months * age 18 years or older * willing and able to provide informed consent * assessed to be safe and able to exercise by unit HD Nephrologist Exclusion Criteria: * regular vigorous exercise outside of hemodialysis * over 79 years of age * intradialytic exercise \< 3 months * poor echogenicity * acute coronary syndrome in the past 3 months * unstable arrhythmia/angina * shortness of breath at rest or with minimal activity * symptomatic hypoglycemia (\>2x/week in the week prior to enrolment)

Primary outcome measure(s)

Change in the number of left ventricular segments undergoing a greater than 20% reduction in longitudinal strain as detected by echocardiogram — week 1 to week 4
An echocardiogram will be completed pre-hemodialysis (HD) treatment and at peak hemodynamic stress (30 min before the end of HD treatment) at each of the four study sessions. Images will be captured in the left lateral position and standard apical 4, 2, and 3 chamber views will be recorded for analysis using automated speckle-tracking software (EchoPac, GE Healthcare)

Trial sites (1)

Facility	City	Region	Status
London Health Sciences Centre	London	Ontario	Recruiting

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Other trials for the same condition

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06735378 on ClinicalTrials.gov ↗ ← All trials in Canada