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Clinical Trials in Canada / NCT07112339
Recruiting Phase 4

A Research Study to See How Well Weekly Insulin Icodec Maintains Blood Sugar Levels Compared to Daily Basal Insulins in Adults With Type 2 Diabetes

NCT07112339 · tracked via the Priya Life Science Canada tracker
Phase
Phase 4
Started
2025-08-15
Last updated
2026-08-11

Condition(s) studied

Diabetes Mellitus, Type 2

Investigational drug(s) / intervention(s)

Insulin icodec →Basal insulin analogues

Insulin icodec: Insulin icodec will be administered as subcutaneous injection.

Basal insulin analogues: Basal insulin analogues will be administered as subcutaneous injection.

Study summary

This study compares insulin icodec, taken once a week, with other basal insulins, taken once a day, in people with type 2 diabetes.The purpose of this study is to see how well the approved injectable weekly insulin icodec maintains blood sugar levels when compared to approved and available daily injectable basal insulins in people with type 2 diabetes. The participants will either be prescribed weekly insulin icodec or a daily basal insulin (insulin glargine, insulin detemir or insulin degludec) based on current standards for the treatment of type 2 diabetes. The study will last for about 13 months.

Eligibility

Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria: * Diagnosed with T2D greater than or equal to (≥) 180 days prior to the day of screening. * Treatment with any of the following non-insulin glucose-lowering medication(s) or combination regimen(s) at the time of screening: Metformin, Sulfonylureas, Meglitinides (glinides), dipeptidyl peptidase-4 (DPP-4) inhibitors, sodium-glucose cotransporter-2 (SGLT2) inhibitors, Thiazolidinediones, Alpha-glucosidase inhibitors, Oral combination products (for the allowed individual oral antidiabetic drugs), Oral or injectable glucagon-like peptide-1 (GLP-1) receptor agonists and Injectable dual glucose-dependent insulinotropic polypeptides (GIP) and GLP-1 receptor agonist. * Need of intensification with basal insulin, as indicated at the discretion of the investigator. * Recorded HbA1c value ≥7% within the last 90 days prior to randomization. Exclusion Criteria: * Known or suspected hypersensitivity to study intervention(s) or related products. * Previous participation in this study. Participation is defined as signed informed consent. * Female who is pregnant, breast-feeding or intends to become pregnant or is of child-bearing potential and not using adequate contraceptive method. * Participation (i.e., received any study intervention) in any interventional clinical study within 90 days before screening. * Any disorder which in the investigator's opinion might jeopardize participant's safety.

Primary outcome measure(s)

Trial sites (75)

FacilityCityRegionStatus
Centricity Research Calgary Endocrinology Calgary Alberta Recruiting
Alta Clinical Research at Hermitage Medicentre Edmonton Alberta Recruiting
Fraser Clinical Trials Inc. New Westminster British Columbia Recruiting
Winnipeg Clinic Winnipeg Manitoba Recruiting
G.A. Research Associates Ltd. Moncton New Brunswick Recruiting
Centricity Research Brampton Endocrinology Brampton Ontario Recruiting
Centricity Clinical Research Burlington Burlington Ontario Completed
Centricity Research Vaughn Endocrinology Concord Ontario Recruiting
Medical Trust Clinics, Inc. Courtice Ontario Completed
Centricity Research Etobicoke Endocrinology Etobicoke Ontario Recruiting
Janik Research Greater Sudbury Ontario Recruiting
Hamilton Medical Research Group Hamilton Ontario Recruiting
St. Josephs Health Care London Ontario Recruiting
Western Univ. Cnt for Studies in Fam Med London Ontario Recruiting
Malton Medical Clinic Mississauga Ontario Completed
Centricity Research Ottawa LMC Nepean Ontario Recruiting
The Ottawa Hospital_Riverside Ottawa Ontario Not Yet Recruiting
Bluewater Clin Res Group Inc Sarnia Ontario Completed
Sewa Ram Singal Medicine Professional Corp Toronto Ontario Recruiting
Centricity Research Toronto Toronto Ontario Recruiting
Centricity Research Toronto Manna Multispec Toronto Ontario Completed
Diex Recherche Joliette Joliette Quebec Recruiting
Alpha Recherche Clinique - Clinique de Levis Lévis Quebec Recruiting
Centricity Research Mirabel Mirabel Quebec Recruiting
Centre hospitalier de l'Universite de Montreal Montreal Quebec Not Yet Recruiting
McGill University Health Centre Montreal Quebec Not Yet Recruiting
Applied Medical Informatics Research Montreal Quebec Recruiting
Clinique Endocrinologie OASIS. Montreal Quebec Recruiting
Centricity Res Pointe-Claire Pointe-Claire Quebec Recruiting
ALPHA Recherche Clinique Québec Quebec Completed
Diex Recherche Sherbrooke Sherbrooke Quebec Completed
Centre de Recherche Saint-Louis Sherbrooke Quebec Recruiting
Ctr de Med Metab de Lanaudiere Terrebonne Quebec Recruiting
Diex Recherche Trois-Rivieres Trois-Rivières Quebec Recruiting
Diex Recherche Victoriaville Victoriaville Quebec Recruiting
Recherche Clinique Sigma Inc. Québec Canada Recruiting
Diex Recherche Quebec Québec Canada Recruiting
Centre de Recherche Saint-Louis Québec Canada Recruiting
Alpha Recherche Clinique - Lebourgneuf Québec Canada Recruiting
Versdias - Diabetologikum Amberg Amberg Bavaria Recruiting

+ 35 more sites — see the full list on the official registry below.

More Novo Nordisk A/S trials in Canada

Other trials for the same condition

Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07112339 on ClinicalTrials.gov ↗ ← All trials in Canada