Epinephrine Injection: Epinephrine administered via sterile epinephrine injection USP, by 0.3mg or 0.5mg epinephrine auto-injector(s) and/or pre-filled syringe (exact dose).
Study summary
This is a pragmatic, two-arm, open-label, prospective stepped-wedge cluster quasi randomized control trial (SW-CRCT) looking to evaluate early intramuscular (IM) epinephrine in the management of pediatric out-of-hospital cardiac arrest (POHCA).
Eligibility
Sex
ALL
Min age
1 Day
Max age
17 Years
Healthy volunteers
No
Inclusion Criteria:
* Children aged 1 day to and including 17 years experiencing an out-of-hospital cardiac arrest (OHCA)
* Must be receiving at least 1 minute of CPR by trained first responders (police, fire, or paramedic services)
Exclusion Criteria:
\- Children who experience OHCA due to an obvious traumatic event.
Primary outcome measure(s)
Time to initial return of spontaneous circulation (ROSC) — At time of event The primary outcome will be the time to initial ROSC. The investigator will compare time to initial ROSC between the standard of care and intervention periods.
Trial sites (1)
Facility
City
Region
Status
Children's Hospital - London Health Sciences Centre
London
Ontario
Recruiting
More London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's trials in Canada
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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