Phonosurgery: Gender-affirming voice surgery (such as glottoplasty, cricothyroid approximation, thyroplasty and chondrolaryngoplasty), in addition to gender-affirming voice training and hormone therapy, plays an important role in achieving a gender-congruent voice in transgender and gender diverse people. In addition, these interventions are sometimes performed on cisgender men or women who wish to change their voice. However, the impact of these interventions on broad voice characteristics needs to be further investigated.
Mastectomy/breast augmentation: Control group of PFAB and PMAB persons undergoing a mastectomy or breast augmentation surgery.
Study summary
The purpose of this study is to measure the short- and long-term voice outcome and outcome predictors of glottoplasty, cricothyroid approximation, thyroplasty, and chondrolaryngoplasty using a prospective non-randomized controlled trial and a multidimensional voice assessment protocol. Secondly, a laryngeal magnetic resonance imaging protocol will be developed to measure pre- and postoperative anatomical factors and compare them with the acoustic changes.
Eligibility
Sex
ALL
Min age
18 Years
Max age
70 Years
Healthy volunteers
Accepted
PURPOSE 1:
Inclusion criteria for surgery participants:
* Persons who will soon undergo surgery on the vocal folds and/or larynx (including glottoplasty, cricothyroid approximation, thyroplasty and/or thyroid chondroplasty) at UZ Gent
* At least 18 years old
* Sufficient command of the Dutch language for understanding the informed consent letter and completing Dutch questionnaires
Inclusion criteria for volunteers to provide speech samples:
\- Cisgender men or women
Inclusion criteria for volunteer listeners for the listening experiment:
* Dutch-speaking
* Self-reported normal hearing
PURPOSE 2: same as above.
PURPOSE 3:
Inclusion criteria for the healthy participants:
* At least 18 years old
* Sufficient command of the Dutch language to complete a Dutch questionnaire
Exclusion criteria for the healthy participants:
\- One or more contraindications for an MRI examination. These contraindications are checked using a questionnaire (safety checklist).
Inclusion criteria for the pre- and postoperative MRI participants:
\- Random selection of +- 10 participants of purpose 1.
Exclusion criteria for the pre- and postoperative MRI participants:
\- One or more contraindications for an MRI examination. These contraindications are checked using a questionnaire (safety checklist).
Primary outcome measure(s)
Speaking fo — pre, post 1 (1 week), post 2 (1 month), post 3 (6 months), post 4 (1 year) Speaking fundamental frequency
FF 1-5 — pre, post 1 (1 week), post 2 (1 month), post 3 (6 months), post 4 (1 year) Formant frequencies 1-5
Perceptual femininity/masculinity score — pre, post 1 (1 week), post 2 (1 month), post 3 (6 months), post 4 (1 year) Self-perception and listener perceptions of femininity and masculinity. Visual analogue scale (0 = very masculine, 100 = very feminine).
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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