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Clinical Trials in Australia / NCT07195916
Recruiting Phase 1

A Study to Evaluate INCA036873 in Participants With Advanced Solid Tumors and Hematological Malignancies

NCT07195916 · tracked via the Priya Life Science Australia tracker
Phase
Phase 1
Started
2026-01-08
Last updated
2026-09-15

Condition(s) studied

Solid TumorsHematologic Malignancies

Investigational drug(s) / intervention(s)

INCA036873

INCA036873: Intravenously (IV)

Study summary

A study to evaluate the safety and tolerability of INCA036873 in participants with advanced solid tumors and hematological malignancies.

Eligibility

Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria: * Age ≥18 years. * ECOG performance status of 0 or 1. * Histologically confirmed: * Clear cell renal cell carcinoma (ccRCC). * Diffuse large B-cell lymphoma (DLBCL, NOS). * High-grade B-cell lymphoma (HGBCL). * Peripheral T-cell lymphoma (PTCL, incl. NOS and ALCL). * Cutaneous T-cell lymphoma (CTCL, incl. MF or SS ≥Stage IIB with B0/B1 blood involvement). * Disease progression, relapse, or refractory to prior therapy: * ccRCC: ≥1 prior line incl. ICI + TKI. * DLBCL/HGBCL: ≥2 prior lines incl. immunochemotherapy and salvage. * PTCL/CTCL: ≥1 prior systemic therapy. * Measurable disease by RECIST v1.1 (ccRCC), Lugano 2014 (lymphomas), or ISCL/USCLC/EORTC (CTCL). * Tumor tissue available for central testing. Exclusion Criteria: * Untreated or progressive CNS disease unless previously treated and stable. * Other active invasive malignancy within 2 years (except certain low-risk cancers). * Prior CD70-targeting therapy, including CAR T. * ASCT or CAR T ≤12 weeks before enrollment; prior organ or allogeneic transplant. * Unresolved ≥Grade 2 toxicity from prior therapy (with exceptions). * Primary immunodeficiency or active autoimmune disease requiring immunosuppression. * Active HBV, HCV, HIV, or other chronic infections requiring systemic therapy. * Pregnancy, breastfeeding, or unwillingness to use effective contraception. Other protocol-defined Inclusion/Exclusion Criteria may apply.

Primary outcome measure(s)

Trial sites (22)

FacilityCityRegionStatus
City of Hope Medical Center Duarte California Recruiting
University of California San Diego Medical Center, Moores Cancer Center La Jolla California Recruiting
University of Michigan Ann Arbor Michigan Recruiting
The University of Nebraska Medical Center Omaha Nebraska Recruiting
Memorial Sloan Kettering Cancer Center New York New York Recruiting
Scri Oncology Partners Nashville Tennessee Recruiting
Vanderbilt Medical Center Nashville Tennessee Not Yet Recruiting
Md Anderson Cancer Center Houston Texas Recruiting
Macquarie University Hospital Sydney New South Wales Recruiting
Princess Alexandra Hospital Australia Woolloongabba Queensland Recruiting
Cancer Research Sa Adelaide South Australia Recruiting
Peter Maccallum Cancer Centre-Royal Melbourne Hospital Melbourne Victoria Recruiting
Cliniques Universitaires Ucl Saint-Luc Brussels Belgium Recruiting
Universitair Ziekenhuis Antwerpen Edegem Belgium Recruiting
Universitair Ziekenhuis Gent (Uz Gent) Ghent Belgium Recruiting
Universitair Ziekenhuis Leuven Leuven Belgium Recruiting
Aarhus University Hospital Aarhus Denmark Not Yet Recruiting
Rigshospitalet Uni of Hospital of Copenhagen Copenhagen Denmark Recruiting
Aou Policlinico S. Orsola-Malpighi Bologna Italy Not Yet Recruiting
Fondazione Irccs Istituto Nazionale Dei Tumori Milan Italy Not Yet Recruiting
Policlinico Universitario Agostino Gemelli Universita Cattolica Del Sacro Cuore Rome Italy Not Yet Recruiting
Centro Ricerche Cliniche Di Verona Verona Italy Not Yet Recruiting

More Incyte Corporation trials in Australia

Other trials for the same condition

Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07195916 on ClinicalTrials.gov ↗ ← All trials in Australia