CTCA results: Participants who are assigned to CTCA group will receive their CTCA results
PRS results: Participants who are assigned to PRS group will receive their PRS results
Study summary
This study is a three-arm, parallel-group, randomised controlled trial evaluating the effect of using cardiac CT imaging or polygenic risk score in cardiovascular risk factor modification in patients with diabetes.
Eligibility
Sex
ALL
Min age
40 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria:
* Age 40 years or older
* Established diagnosis of T2DM
* Having acceptable imaging quality as deemed by the VHI-AICL
* Able to have a PRS calculated
Exclusion Criteria:
* Unable to provide written informed consent.
* Unwilling to be followed for serial evaluation
* Clinically manifest CV disease
* Evidence of clinically significant coronary disease on CT that would preclude masking from participant's treating clinician for the duration of the study on the grounds of safety, including but not limited to, equal/greater than 50% in the left main coronary artery or equal/greater than 70% in any epicardial coronary artery
* Unable to participate in the study or complete protocol required assessments in the opinion of the Investigator
Primary outcome measure(s)
Change in non-calcified plaque volume, with Bonferroni correction at 12 months — From baseline CT to the end of study at 12 months
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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