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Clinical Trials in Australia / NCT05180942
Recruiting Observational

Statins and prOgression of Coronary atheRosclerosis in melanomA Patients Treated With chEckpoint inhibitorS

NCT05180942 · tracked via the Priya Life Science Australia tracker
Phase
Observational
Started
2022-11-07
Last updated
2025-08-27

Condition(s) studied

MelanomaAtherosclerosis

Study summary

This study is a prospective observational study evaluating the natural history of coronary plaque burden in participants with melanoma treated with ICI. The study will be conducted at various sites across Australia.

Eligibility

Sex
ALL
Min age
40 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria: * Capable of providing informed consent and willing to adhere to all protocol requirements * patients aged \> or equal to 40 years * Histologically confirmed melanoma of any stage planned for, commenced, or completed treatment with ICI * having acceptable imaging quality deemed by the core laboratory * Investigator believes that the participant is willing to adhere to all protocol requirements, including returning for follow up CTCA. Exclusion Criteria: * Known clinically manifest cardiovascular disease * Female participants must not be pregnant, breastfeeding or plan to become pregnant during the study. * Estimated glomerular filtration rate of \<45 mL/min calculated using the Chronic Kidney Disease Epidemiology Collaboration equation * Severe liver disease or cirrhosis * History of any other malignancy within the past 5 years in addition to melanoma with the exception of non-melanoma skin cancers * Prognostic factors associated with an expected survival less than 18 months at Investigators' discretion (e.g. unresectable brain metastases) * Evidence of any other clinically significant non-cardiac disease or condition that, in the opinion of the Investigator, would preclude participation in the study * Major allergy to iodine * Participation in another clinical trial that does not allow participation in multiple trials at the same time

Primary outcome measure(s)

Trial sites (12)

FacilityCityRegionStatus
Nepean Hospital Kingswood New South Wales Recruiting
Calvary Mater Newcastle Waratah New South Wales Recruiting
Bundaberg Base Hospital Bundaberg Queensland Recruiting
Hervey Bay Hospital Hervey Bay Queensland Recruiting
Ipswich Hospital Ipswich Queensland Recruiting
Toowoomba Hospital Toowoomba Queensland Recruiting
Queen Elizabeth Hospital Woodville South South Australia Recruiting
Monash Health Clayton Victoria Recruiting
Peninsula Health Frankston Victoria Recruiting
Cabrini Health Malvern Victoria Recruiting
Peter MacCallum Cancer Centre Melbourne Victoria Recruiting
Mildura Public Base Hospital Mildura Victoria Recruiting

More Monash University trials in Australia

Other trials for the same condition

Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT05180942 on ClinicalTrials.gov ↗ ← All trials in Australia