Atorvastatin 40 Mg Oral Tablet: 40 mg atorvastatin (2 x 20 mg atorvastatin daily), taken orally
Placebo: 2 x 20mg placebo (daily), taken orally. Identical appearance to study drug
Study summary
The STAREE-Mind imaging sub-study will examine the effect of statin treatment over a 4-year period, compared with placebo, on markers of brain health.
Eligibility
Sex
ALL
Min age
70 Years
Max age
—
Healthy volunteers
Accepted
Inclusion Criteria:
* Participants in the STAREE RCT and eligible for randomisation to study medication.
* Men and women
* Aged ≥70 years
* Living independently in the community
* Willing and able to provide informed consent and agree to participate in brain neuroimaging.
* Able to attend one of the 2 sites (in Melbourne and Brisbane) where the imaging will take place.
Exclusion Criteria:
* Contraindications to have magnetic resonance neuroimaging performed.
* History of invasive brain surgery or known structural bran abnormalities.
Primary outcome measure(s)
Free water — Change from baseline to four years Multi-compartment free water quantitation from brain diffusion-weighted MRI
White matter hyperintensity volume — Change from baseline to four years From brain FLAIR MRI
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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