Neurofilament Light Chain And Voice Acoustic Analyses In Dementia Diagnosis

NCT06339190 · tracked via the Priya Life Science Australia tracker

Sponsor

Monash University

Phase

Observational

Started

2021-08-01

Last updated

2025-05-30

Condition(s) studied

Neurodegenerative DiseasesDementia

Investigational drug(s) / intervention(s)

Venepuncture

Venepuncture: A single blood draw at the time of presentation to clinic or whilst an inpatient.

Study summary

This cohort study aims to determine if a blood test can aid with diagnosing dementia in anyone presenting with cognitive complaints to a single healthcare network. The investigators will measure levels of a brain protein, Neurofilament light chain (Nfl), and assess changes in language using speech tests.

Participants will have a single blood test and speech test, and will be followed up at 12-months to complete questionnaires and cognitive scales over the phone. The speech test will also be completed again at 12-months.

Individuals at risk of a Fronto-temporal dementia syndrome will be eligible to complete optional genetic testing involving an 'at home' saliva sample.

Eligibility

Sex

ALL

Min age

—

Max age

—

Healthy volunteers

Inclusion Criteria: * All patients presenting to Eastern Health services with a cognitive complaint or potential neurodegenerative disorder Exclusion Criteria: * Prognosis \<12 months * No cognitive complaint * Patients not involved within the single healthcare network

Primary outcome measure(s)

Baseline NfL level — Day 0
Plasma Nfl (pg/ml), estimated using Quanterix SIMOA HD-X

Trial sites (2)

Facility	City	Region	Status
Box Hill Hospital	Box Hill	Victoria	Recruiting
Wantirna Health	Wantirna	Victoria	Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06339190 on ClinicalTrials.gov ↗ ← All trials in Australia