De-escalation of Radiation Dose in HPV-associated OPC Utilising FMISO PET (DE-RADIATE)

NCT06307015 · tracked via the Priya Life Science Australia tracker

Sponsor

Royal North Shore Hospital

Phase

Not applicable

Started

2025-04-01

Last updated

2025-07-30

Condition(s) studied

HPV Positive Oropharyngeal Squamous Cell Carcinoma

Investigational drug(s) / intervention(s)

De-escalationStandard of care

De-escalation: Surgical resection of primary oropharyngeal tumour followed by de-escalated radiation therapy (30Gy) with concurrent platinum-based chemotherapy to oropharynx + neck, followed by surgical neck dissection

Standard of care: Radiation therapy (70Gy) with concurrent platinum-based chemotherapy to oropharynx + neck

Study summary

The goal of this prospective clinical trial is to determine if HPV-associated oropharyngeal squamous cell carcinoma that is non-hypoxic on FMISO PET can be successfully treated with a lower dose of radiation therapy.

The main questions it aims to answer are:

1. What is the pathologic complete response rate in patients selected for radiation dose de-escalation and neck dissection?
2. What is the correlation between MRI and FMISO PET assessment of hypoxia before and during RT?
3. What are the acute and late toxicities in patients selected for radiation dose de-escalation?
4. What are the quality of life scores in patients selected for radiation dose de-escalation?
5. What are the local, regional and distant failure rates of patients selected for radiation dose de-escalation?

Patients with cT1-2N1-2b (AJCC 7th edition) oropharyngeal tumours will undergo surgical resection of the primary tumour. Following this, they will be allocated to standard radiation therapy (70Gy with concurrent cisplatin chemotherapy) or de-escalation radiation therapy (30Gy with concurrent cisplatin chemotherapy) based on the results of FMISO PET. Patients with non-hypoxic tumours at baseline OR after two weeks of radiation therapy will be allocated to the de-escalated group. 3-4 months after completion of radiation therapy, all patients in the de-escalated group will undergo mandatory neck dissection to assess pathologic response.

Researchers will assess the pathologic response rate after surgery in the de-escalation group. They will also compare the outcomes (oncological outcomes and quality of life) between the group receiving the standard treatment (70Gy) and the group receiving de-escalated radiation therapy (30Gy).

Eligibility

Sex

ALL

Min age

18 Years

Max age

—

Healthy volunteers

Inclusion Criteria: * Age \> 18 years * Histologically confirmed cT1-2N1-2b oropharyngeal squamous cell carcinoma or cTxN1-2 carcinoma of unknown primary * p16 positive (70% nuclear and cytoplasmic staining) and HPV positive (genotyping via PCR) tumours of the tonsil, base of tongue, glossotonsillar sulcus, or unknown primary site (suspected mucosal origin). * No contraindications to radiotherapy, platinum-based chemotherapy or surgery * No contraindications to PET/CT or MRI * Eastern Cooperative Oncology Group (ECOG) performance status score 0-2 (KPS \> 70%) * Ability to understand and willingness to sign a written informed consent document Exclusion Criteria: * Women lactating, pregnant or of childbearing potential who are not willing to avoid pregnancy during the study * Patients with a history of severe renal disease(s) (eGFR \<20) than cannot tolerate gadolinium chelate contrast agents.) * ECOG ≥ 3 * Previous high dose radiation therapy to the head or neck * Patients unwilling or unable to have PET/CT or MRI * Geographically remote patients unable to agree to imaging schedule * Patients with a history of psychological illness or condition such as to interfere with the patient's ability to understand the requirements of the study. * Patients with significant cardiac or pulmonary disease including cardiac arrythmias or Chronic Obstructive Pulmonary Disease (COPD) that are unable to tolerate high flow O2 for oxygen contrast. * Patients taking carbonic anhydrase inhibitors (acetazolamide) * History of glaucoma * Any implant, foreign body, 3T MRI incompatible device, or other contraindication to MRI imaging

Primary outcome measure(s)

Pathologic complete response — 4 months after completion of radiation therapy
Pathologic complete response in surgical neck dissection

Trial sites (1)

Facility	City	Region	Status
Northern Sydney Cancer Centre, Royal North Shore Hospital	Saint Leonards	New South Wales	Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06307015 on ClinicalTrials.gov ↗ ← All trials in Australia