Clinical Trials in Massachusetts

Every industry-sponsored study on the ClinicalTrials.gov registry that lists a US site and is open, about to open, active-but-closed, or enrolling by invitation. This deliberately excludes academic and other non-industry sponsors — the full US registry across all sponsors runs to over 22,000 recruiting studies alone.

Status

Study

Lead sponsor

Phase

Enrol

US states

Start

Recruiting

Study of RMC-5127 in Patients With Advanced KRAS G12V-Mutant Solid Tumors

NCT07349537Non-small Cell Lung Cancer (NSCLC), Colorectal Cancer (CRC), Pancreatic Adenocarcinoma, Pancreatic Ductal Adenocarcinoma (PDAC)

Revolution Medicines, Inc.

Phase 1

574

Connecticut, Maryland, Massachusetts, Michigan, New York, Texas, Virginia

2026-01-08

Recruiting

KO-2806 Monotherapy and Combination Therapies in Advanced Solid Tumors

NCT06026410Solid Tumors With HRAS Alterations, Non Small Cell Lung Cancer (NSCLC), Colorectal Cancer (CRC), Pancreatic Ductal Adenocarcinoma (PDAC)

Kura Oncology, Inc.

Phase 1

300

Arizona, California, Colorado, Florida, Iowa, Massachusetts, Michigan, Minnesota

2023-10-18

Recruiting

Study of RMC-9805 in Participants With KRAS G12D-Mutant Solid Tumors

NCT06040541Non-small Cell Lung Cancer (NSCLC), Colorectal Cancer (CRC), Pancreatic Ductal Adenocarcinoma (PDAC), Advanced Solid Tumors

Revolution Medicines, Inc.

Phase 1

604

California, Connecticut, Florida, Maryland, Massachusetts, New York, North Carolina, Ohio

2023-09-07

Active, closed

Dose Escalation and Dose Expansion Study of RMC-6291 Monotherapy in Subjects With Advanced KRASG12C Mutant Solid Tumors

NCT05462717Non-Small Cell Lung Cancer (NSCLC), Colorectal Cancer (CRC), Pancreatic Ductal Adenocarcinoma, Advanced Solid Tumor

Revolution Medicines, Inc.

Phase 1

222

Arkansas, California, Florida, Maryland, Massachusetts, New York, Tennessee, Texas

2022-09-19

Recruiting

Study of RMC-6236 in Patients With Advanced Solid Tumors Harboring Specific Mutations in RAS

NCT05379985Non-small Cell Lung Cancer (NSCLC), Colorectal Cancer (CRC), Pancreatic Ductal Adenocarcinoma (PDAC), Advanced Solid Tumors

Revolution Medicines, Inc.

Phase 1/2

754

California, Florida, Georgia, Louisiana, Maryland, Massachusetts, New York, Ohio

2022-05-31

Recruiting

Collection of Samples USOPTIVAL Study

NCT04792684Colorectal Cancer (CRC), Advanced Adenomas (AA)

Universal Diagnostics

Observational

1,300

California, Florida, Illinois, Louisiana, Massachusetts, New York, Pennsylvania, Tennessee

2020-12-30

Cite this view

Priya Life Science (2026). Clinical trial register: industry-sponsored studies with a US investigative site, filtered. Derived from ClinicalTrials.gov. Retrieved 17 September 2026. https://priyalifescience.com/clinical-trials-usa/state/massachusetts

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