The main purpose of this study is to find out how significantly Eloralintide slows stomach emptying in participants who are overweight or obese. For each participant, the study will last approximately 21 weeks and will include 2 overnight stays in the clinical research unit (CRU) lasting between 4 and 8 days. There will be 13 other visits.
Eligibility
Sex
ALL
Min age
18 Years
Max age
65 Years
Healthy volunteers
Accepted
Inclusion Criteria:
* Have overweight or obesity, but are otherwise overtly healthy.
* Have a body mass index (BMI) within the range of 27.0 to 45.0 kilograms (kg)/square meter (m²), inclusive.
* Have had a stable body weight, with less than 5 percent (%) change during the 3-month period prior to screening.
Exclusion Criteria:
* Have been diagnosed with Type 1 or Type 2 diabetes mellitus, or have either of the following at screening
* A fasting plasma glucose concentration greater than or equal to 126 milligrams (mg)/deciliter (dL) or 7.0 millimoles (mmol)/liter (L), or
* Hemoglobin A1C (HbA1c) greater than or equal to 6.5% or 48 mmol/mole (mol).
* Have a history or presence of psychiatric disorders, including a history of major depressive disorder or severe psychiatric disorders such as schizophrenia, and bipolar disorder, within the last 2 years.
* Have received a glucagon-like peptide-1 (GLP-1) receptor agonist, glucose-dependent insulinotropic polypeptide (GIP)/GLP-1 receptor agonist, or GIP/GLP-1/glucagon receptor agonist within 60 days or 5 half-lives, whichever is longer, prior to screening.
* Are in the judgment of the investigator, actively suicidal or deemed to be at significant risk for suicide.
Primary outcome measure(s)
Acetaminophen Area Under the Concentration Versus Time Curve (AUC) — Baseline to Day 65
Acetaminophen Maximum Observed Concentration (Cₘₐₓ) — Baseline to Day 65
Acetaminophen Time to Maximum Observed Drug Concentration (tₘₐₓ) — Baseline to Day 65
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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