A Study to Evaluate Mezigdomide, Bortezomib and Dexamethasone (MEZIVd) Versus Pomalidomide, Bortezomib and Dexamethasone (PVd) in Participants With Relapsed or Refractory Multiple Myeloma (RRMM)
Condition(s) studied
Investigational drug(s) / intervention(s)
mezigdomide: Specified dose on specified days
Pomalidomide: Specified dose on specified days
Bortezomib: Specified dose on specified days
Dexamethasone: Specified dose on specified days
Study summary
The purpose of this study is to compare the efficacy and safety of mezigdomide (CC-92480), bortezomib and dexamethasone (MeziVd) versus pomalidomide, bortezomib and dexamethasone (PVd) in participants with relapsed or refractory multiple myeloma (RRMM) who received between 1 to 3 prior lines of therapy and who have had prior lenalidomide exposure.
Eligibility
Primary outcome measure(s)
- Progression-free Survival (PFS) — From date of randomization to date of disease progression or death due to any cause (Up to approximately 5 years)
Trial sites (266)
| Facility | City | Region | Status |
|---|---|---|---|
| Local Institution - 0366 | Los Alamitos | California | Active Not Recruiting |
| Local Institution - 0272 | San Diego | California | Completed |
| Local Institution - 0273 | West Hollywood | California | Completed |
| Local Institution - 0381 | Aurora | Colorado | Not Yet Recruiting |
| Local Institution - 0380 | Farmington | Connecticut | Completed |
| Local Institution - 0208 | New Haven | Connecticut | Withdrawn |
| Local Institution - 0303 | Coral Springs | Florida | Active Not Recruiting |
| Local Institution - 0403 | Fort Myers | Florida | Completed |
| Local Institution - 0401 | Orange City | Florida | Active Not Recruiting |
| Local Institution - 0402 | West Palm Beach | Florida | Active Not Recruiting |
| Local Institution - 0211 | Athens | Georgia | Active Not Recruiting |
| Local Institution - 0048 | Marietta | Georgia | Withdrawn |
| Local Institution - 0330 | Garden City | Kansas | Completed |
| Local Institution - 0080 | Westwood | Kansas | Active Not Recruiting |
| Local Institution - 0358 | Baton Rouge | Louisiana | Active Not Recruiting |
| Local Institution - 0255 | New Orleans | Louisiana | Active Not Recruiting |
| Local Institution - 0385 | Shreveport | Louisiana | Not Yet Recruiting |
| Local Institution - 0357 | Baltimore | Maryland | Completed |
| Local Institution - 0246 | Boston | Massachusetts | Active Not Recruiting |
| Local Institution - 0271 | Ann Arbor | Michigan | Active Not Recruiting |
| Local Institution - 0364 | Detroit | Michigan | Completed |
| Local Institution - 0410 | Minneapolis | Minnesota | Active Not Recruiting |
| Local Institution - 0088 | Hattiesburg | Mississippi | Active Not Recruiting |
| Local Institution - 0242 | Jackson | Mississippi | Withdrawn |
| Local Institution - 0288 | East Brunswick | New Jersey | Active Not Recruiting |
| Local Institution - 0363 | Ridgewood | New Jersey | Not Yet Recruiting |
| Local Institution - 0302 | Albuquerque | New Mexico | Active Not Recruiting |
| Local Institution - 0245 | Buffalo | New York | Withdrawn |
| Local Institution - 0257 | Lake Success | New York | Active Not Recruiting |
| Local Institution - 0373 | New Hyde Park | New York | Completed |
| Local Institution - 0371 | New York | New York | Completed |
| Local Institution - 0108 | Rochester | New York | Active Not Recruiting |
| Local Institution - 0374 | Shirley | New York | Completed |
| Local Institution - 0372 | The Bronx | New York | Completed |
| Local Institution - 0274 | Williamsville | New York | Withdrawn |
| Local Institution - 0260 | Durham | North Carolina | Active Not Recruiting |
| Local Institution - 0400 | Cincinnati | Ohio | Completed |
| Local Institution - 0377 | Cleveland | Ohio | Active Not Recruiting |
| Local Institution - 0076 | Cleveland | Ohio | Active Not Recruiting |
| Local Institution - 0376 | Mayfield Heights | Ohio | Completed |
+ 226 more sites — see the full list on the official registry below.
More Celgene trials in the UK
Other trials for the same condition
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
View NCT05519085 on ClinicalTrials.gov ↗ ← All trials in the UK