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Clinical Trials in the UK / NCT05519085
Recruiting Phase 3

A Study to Evaluate Mezigdomide, Bortezomib and Dexamethasone (MEZIVd) Versus Pomalidomide, Bortezomib and Dexamethasone (PVd) in Participants With Relapsed or Refractory Multiple Myeloma (RRMM)

NCT05519085 · tracked via the Priya Life Science UK tracker
Sponsor
Celgene
Phase
Phase 3
Started
2022-09-20
Last updated
2026-09-09

Condition(s) studied

Relapsed or Refractory Multiple Myeloma

Investigational drug(s) / intervention(s)

mezigdomidePomalidomideBortezomibDexamethasone

mezigdomide: Specified dose on specified days

Pomalidomide: Specified dose on specified days

Bortezomib: Specified dose on specified days

Dexamethasone: Specified dose on specified days

Study summary

The purpose of this study is to compare the efficacy and safety of mezigdomide (CC-92480), bortezomib and dexamethasone (MeziVd) versus pomalidomide, bortezomib and dexamethasone (PVd) in participants with relapsed or refractory multiple myeloma (RRMM) who received between 1 to 3 prior lines of therapy and who have had prior lenalidomide exposure.

Eligibility

Sex
ALL
Min age
18 Years
Max age
Healthy volunteers
No
Inclusion Criteria \- Participant has documented diagnosis of MM and measurable disease, defined as any of the following:. i) M-protein ≥ 0.5 grams per deciliter (g/dL) by serum protein electrophoresis (sPEP) or. ii) M-protein ≥ 200 milligrams (mg) per 24-hour urine collection by urine protein electrophoresis (uPEP). iii) For participants without measurable disease in sPEP or uPEP: serum free light chain (sFLC) levels \> 100 mg/L (10 mg/dL) involved light chain and an abnormal kappa/lambda FLC ratio. * Participants received 1 to 3 prior lines of antimyeloma therapy. * Participants achieved minimal response \[MR\] or better to at least 1 prior antimyeloma therapy. Exclusion Criteria \- Participant has had progression during treatment or within 60 days of the last dose of a proteasome inhibitor, except as noted below:. i) Subjects who progressed while being treated with, or within 60 days of last dose of bortezomib maintenance given once every 2 weeks (or less frequently) are not excluded. ii) Participants who progressed while being treated with ixazomib monotherapy maintenance ≥ 6 months prior to the time of starting study treatment are not excluded. * For participants with prior treatment of a bortezomib containing regimen, the best response achieved was not a minimal response (MR) or better, or participant discontinued bortezomib due to toxicity. * Participant has had prior treatment with mezigdomide or pomalidomide. * Other protocol-defined Inclusion/Exclusion criteria apply.

Primary outcome measure(s)

Trial sites (266)

FacilityCityRegionStatus
Local Institution - 0366 Los Alamitos California Active Not Recruiting
Local Institution - 0272 San Diego California Completed
Local Institution - 0273 West Hollywood California Completed
Local Institution - 0381 Aurora Colorado Not Yet Recruiting
Local Institution - 0380 Farmington Connecticut Completed
Local Institution - 0208 New Haven Connecticut Withdrawn
Local Institution - 0303 Coral Springs Florida Active Not Recruiting
Local Institution - 0403 Fort Myers Florida Completed
Local Institution - 0401 Orange City Florida Active Not Recruiting
Local Institution - 0402 West Palm Beach Florida Active Not Recruiting
Local Institution - 0211 Athens Georgia Active Not Recruiting
Local Institution - 0048 Marietta Georgia Withdrawn
Local Institution - 0330 Garden City Kansas Completed
Local Institution - 0080 Westwood Kansas Active Not Recruiting
Local Institution - 0358 Baton Rouge Louisiana Active Not Recruiting
Local Institution - 0255 New Orleans Louisiana Active Not Recruiting
Local Institution - 0385 Shreveport Louisiana Not Yet Recruiting
Local Institution - 0357 Baltimore Maryland Completed
Local Institution - 0246 Boston Massachusetts Active Not Recruiting
Local Institution - 0271 Ann Arbor Michigan Active Not Recruiting
Local Institution - 0364 Detroit Michigan Completed
Local Institution - 0410 Minneapolis Minnesota Active Not Recruiting
Local Institution - 0088 Hattiesburg Mississippi Active Not Recruiting
Local Institution - 0242 Jackson Mississippi Withdrawn
Local Institution - 0288 East Brunswick New Jersey Active Not Recruiting
Local Institution - 0363 Ridgewood New Jersey Not Yet Recruiting
Local Institution - 0302 Albuquerque New Mexico Active Not Recruiting
Local Institution - 0245 Buffalo New York Withdrawn
Local Institution - 0257 Lake Success New York Active Not Recruiting
Local Institution - 0373 New Hyde Park New York Completed
Local Institution - 0371 New York New York Completed
Local Institution - 0108 Rochester New York Active Not Recruiting
Local Institution - 0374 Shirley New York Completed
Local Institution - 0372 The Bronx New York Completed
Local Institution - 0274 Williamsville New York Withdrawn
Local Institution - 0260 Durham North Carolina Active Not Recruiting
Local Institution - 0400 Cincinnati Ohio Completed
Local Institution - 0377 Cleveland Ohio Active Not Recruiting
Local Institution - 0076 Cleveland Ohio Active Not Recruiting
Local Institution - 0376 Mayfield Heights Ohio Active Not Recruiting

+ 226 more sites — see the full list on the official registry below.

More Celgene trials in the UK

Other trials for the same condition

Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT05519085 on ClinicalTrials.gov ↗ ← All trials in the UK