This observational study will examine whether signs of increased sensitivity in the nervous system at the beginning of the study are associated with short-term clinical outcomes in adults with chronic nonspecific low back pain. Approximately 180 participants will complete questionnaires about central sensitization, disability, pain, anxiety, and depression at the beginning of the study.
After 6 weeks, disability, pain, and the participant's overall perception of change will be assessed again. The researchers will evaluate whether the initial level of central sensitization is associated with meaningful improvement in disability and perceived treatment benefit. Participants will not be assigned to a treatment as part of this study and will continue to receive routine clinical care.
Eligibility
Sex
ALL
Min age
18 Years
Max age
65 Years
Healthy volunteers
No
Inclusion Criteria:
* Adults aged 18 to 65 years
* Diagnosis of chronic nonspecific low back pain lasting for at least 3 months
* Willingness to participate in the study
* Ability to provide written informed consent
Exclusion Criteria:
* Progressive neurological deficit
* Inflammatory rheumatic disease
* Active malignancy
* History of serious spinal trauma or spinal surgery
* Cognitive impairment that may prevent completion of the assessments or follow-up
* Initiation, dose modification, or change of antidepressant or gabapentinoid treatment within the previous 3 months
* Pregnancy, postpartum period, or breastfeeding
* Inability to provide informed consent
Primary outcome measure(s)
Clinically Meaningful Improvement in the Oswestry Disability Index — Baseline to 6 weeks The proportion of participants who achieve a reduction of at least 30% in the Oswestry Disability Index (ODI) score from baseline. The ODI ranges from 0 to 100, with higher scores indicating greater disability.
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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