MIECC vs Conventional Cardiopulmonary Bypass and Systemic Inflammation in CABG

Condition(s) studied

Investigational drug(s) / intervention(s)

Minimally Invasive Extracorporeal Circulation: Use of a minimally invasive extracorporeal circulation system during coronary artery bypass graft surgery as part of routine clinical care.

Conventional Cardiopulmonary Bypass: Use of conventional cardiopulmonary bypass during coronary artery bypass graft surgery as part of routine clinical care.

Study summary

This prospective observational study evaluates the effects of minimally invasive extracorporeal circulation (MIECC) and conventional cardiopulmonary bypass on systemic inflammatory response in patients undergoing coronary artery bypass graft surgery. Adult patients undergoing elective coronary artery bypass surgery will be observed according to the extracorporeal circulation technique used during surgery. Systemic inflammation will be assessed using routinely available hematologic inflammatory indices, including the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and systemic immune-inflammation index (SII). These parameters will be evaluated preoperatively, at postoperative 6 hours, at postoperative 24 hours, and at hospital discharge. The study will also evaluate selected perioperative and postoperative clinical outcomes in order to compare the inflammatory response associated with MIECC and conventional extracorporeal circulation.

Eligibility

Primary outcome measure(s)

• Neutrophil-to-Lymphocyte Ratio (NLR) — Preoperative baseline, 6 hours after surgery, 24 hours after surgery, and on the morning of hospital discharge, an average of 6 days after surgery.
  NLR will be calculated from routine complete blood count values by dividing the absolute neutrophil count by the absolute lymphocyte count. Values will be compared between the MIECC and conventional cardiopulmonary bypass groups.
• Platelet-to-Lymphocyte Ratio (PLR) — Preoperative baseline, 6 hours after surgery, 24 hours after surgery, and on the morning of hospital discharge, an average of 6 days after surgery.
  PLR will be calculated from routine complete blood count values by dividing the platelet count by the absolute lymphocyte count. Values will be compared between the MIECC and conventional cardiopulmonary bypass groups.
• Systemic Immune-Inflammation Index (SII) — Preoperative baseline, 6 hours after surgery, 24 hours after surgery, and on the morning of hospital discharge, an average of 6 days after surgery.
  SII will be calculated as neutrophil count × platelet count / lymphocyte count using routine complete blood count values. Values will be compared between the MIECC and conventional cardiopulmonary bypass groups.

Trial sites (1)

More Bursa Yuksek Ihtisas Training and Research Hospital trials in Turkey

Other trials for the same condition