Effects of N-acetyl Cysteine During Percutaneous Coronary Intervention

NCT01878669 · tracked via the Priya Life Science Turkey tracker

Sponsor

Suleyman Demirel University

Phase

Phase 3

Started

2013-01

Last updated

2025-05-20

Condition(s) studied

Coronary Artery Disease

Investigational drug(s) / intervention(s)

N-acetyl cysteine →Saline

Study summary

The aim of this study is to evaluate the effects of N-acetyl cysteine on periprocedural myocardial infarction and major cardiac and cerebral events in patients undergoing percutaneous coronary intervention and who have moderate to high risk for contrast induced nephropathy.

Eligibility

Sex

ALL

Min age

18 Years

Max age

85 Years

Healthy volunteers

Inclusion Criteria: * Patients \> 18 years old undergoing percutaneous coronary intervention and who have moderate to high risk for contrast induced nephropathy (Mehran Score ≥ 5) Exclusion Criteria: * Primary percutaneous coronary intervention * Low risk for contrast induced nephropathy (Mehran Score \< 5) * Use of nephrotoxic agents (NSAIDs, aminoglycosides,recent contrast injection...) * Infection * Pregnancy, Lactation * Renal failure requiring dialysis * Hepatic failure * History allergy for NAC * History of Asthma * Chronic nitrate usage * Malignancy * Use of corticosteroids * Leukocytosis,Thrombocytosis,Anemia * Blood pressure of \>180/100mmHg despite anti-hypertensive therapy

Primary outcome measure(s)

periprocedural myocardial infarction — postprocedural 3-6 h

Trial sites (1)

Facility	City	Region	Status
Suleyman Demirel University	Isparta	Mediterranean Region

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT01878669 on ClinicalTrials.gov ↗ ← All trials in Turkey