Chronic SSRI/SNRI Use and Intraoperative Propofol Requirements
Study summary
THE GOAL OF THIS OBSERVATIONAL STUDY IS TO LEARN WHETHER LONG-TERM USE OF SELECTIVE SEROTONIN REUPTAKE INHIBITOR (SSRI) OR SEROTONIN-NOREPINEPHRINE REUPTAKE INHIBITOR (SNRI) ANTIDEPRESSANTS IS RELATED TO THE AMOUNT OF PROPOFOL NEEDED DURING PLANNED SPINE SURGERY. PROPOFOL IS A MEDICINE GIVEN THROUGH A VEIN TO PRODUCE AND MAINTAIN ANESTHESIA.
THE MAIN QUESTIONS THIS STUDY AIMS TO ANSWER ARE:
* DO PATIENTS WHO REGULARLY TAKE AN SSRI OR SNRI NEED A DIFFERENT TOTAL AMOUNT OF PROPOFOL DURING SURGERY THAN PATIENTS WHO DO NOT TAKE THESE MEDICINES?
* ARE THERE DIFFERENCES IN PROPOFOL AND REMIFENTANIL USE, DEPTH OF ANESTHESIA, VITAL SIGNS, OR RECOVERY TIME BETWEEN THE STUDY GROUPS?
THE STUDY WILL INCLUDE 216 ADULTS UNDERGOING PLANNED SPINE SURGERY. RESEARCHERS WILL COMPARE 108 PARTICIPANTS WHO REGULARLY TAKE AN SSRI OR SNRI WITH 108 PARTICIPANTS WHO DO NOT TAKE THESE MEDICINES.
ALL PARTICIPANTS WILL RECEIVE ROUTINE ANESTHESIA CARE. THE STUDY WILL NOT START, STOP, OR CHANGE ANY ANTIDEPRESSANT TREATMENT, AND PARTICIPANTS WILL NOT BE RANDOMLY ASSIGNED TO A GROUP. RESEARCHERS WILL RECORD THE AMOUNT OF PROPOFOL AND REMIFENTANIL USED DURING SURGERY, BLOOD PRESSURE, HEART RATE, OXYGEN LEVEL, DEPTH OF ANESTHESIA, AND RECOVERY TIME.
Eligibility
Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
Accepted
Inclusion Criteria:
* 1\. Study period: Between October 2026 and April 2027, 2. Study location: Kocaeli City Hospital Operating Rooms, 3. Type of surgery: Patients scheduled for spinal surgery, 4. Medication use: Patients using chronic SSRI or SNRI group antidepressants in the preoperative period, but not using antipsychotics or other group antidepressants (e.g., TCA, MAOI, atypical antidepressants), 5. Age criterion: Adult individuals aged 18 and over, 6. ASA classification: Patients in ASA 2-3 group,
Exclusion Criteria:
* 1\. Patients who cannot give informed consent and individuals under 18 years of age, 2. Patients with an ASA (American Society of Anesthesiologists) physical status classification of ASA IV or higher, 3. Cases requiring emergency surgical intervention, 4. Patients undergoing surgery due to trauma, 5. Patients using antidepressants other than selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs), 6. Cases maintained with inhalation anesthesia.
Primary outcome measure(s)
Total Intraoperative Propofol Consumption — From induction of anesthesia until the end of surgery, on the day of surgery The total cumulative dose of propofol administered during anesthetic induction and BIS-guided total intravenous anesthesia maintenance will be recorded in milligrams (mg) for each participant. Total propofol consumption will be compared between participants receiving chronic SSRI/SNRI therapy and control participants.
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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