Low Fresh Gas Flow (0.5 L/min)High Fresh Gas Flow (4 L/min)
Low Fresh Gas Flow (0.5 L/min): General anesthesia will be maintained using a fresh gas flow rate of 0.5 L/min after an initial fresh gas flow of 4 L/min for 8 minutes following endotracheal intubation.
High Fresh Gas Flow (4 L/min): General anesthesia will be maintained using a fresh gas flow rate of 4 L/min after an initial fresh gas flow of 4 L/min for 8 minutes following endotracheal intubation.
Study summary
This prospective randomized clinical trial aims to evaluate the effects of different fresh gas flow rates on postoperative pulmonary aeration using lung ultrasonography in patients undergoing elective laparoscopic cholecystectomy. Patients will be randomly assigned to receive either low-flow anesthesia (0.5 L/min) or high-flow anesthesia (4 L/min) during maintenance of general anesthesia. The primary objective is to compare postoperative lung ultrasound scores and the incidence of atelectasis between the two groups.
Eligibility
Sex
ALL
Min age
18 Years
Max age
65 Years
Healthy volunteers
No
Inclusion Criteria:
* Adults aged 18 years or older.
* American Society of Anesthesiologists (ASA) physical status I-II.
* Scheduled for elective laparoscopic cholecystectomy under general anesthesia.
* Able and willing to provide written informed consent.
Exclusion Criteria:
* Refusal to participate in the study.
* History of chronic respiratory disease, including severe asthma, chronic obstructive pulmonary disease (COPD), or bronchiolitis.
* History of alcohol or substance abuse.
* Intraoperative airway or respiratory complications during endotracheal intubation or surgery.
* Life-threatening postoperative complications.
* Patients with ASA physical status III or higher.
Primary outcome measure(s)
Postoperative Lung Ultrasound Score — 30 minutes after extubation Lung ultrasonography will be performed 30 minutes after extubation. Both lungs will be divided into 12 regions, with 6 regions assessed in each lung. Each region will be scored from 0 to 3: 0 indicates normal aeration with A-lines or fewer than three B-lines; 1 indicates at least three well-spaced B-lines; 2 indicates coalescent B-lines; and 3 indicates lung consolidation. The scores from all regions will be summed, resulting in a total score ranging from 0 to 36. Higher scores indicate greater loss of lung aeration.
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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