Early Kidney Injury Biomarkers in Gynecologic Laparoscopic Surgery

Condition(s) studied

Investigational drug(s) / intervention(s)

Pneumoperitoneum and Trendelenburg Positioning: Standard intraoperative carbon dioxide pneumoperitoneum combined with either 30° or 45° Trendelenburg positioning during laparoscopic surgery

Study summary

This prospective observational study aims to evaluate early subclinical acute kidney injury associated with pneumoperitoneum and Trendelenburg positioning during gynecological laparoscopic surgery. Urinary neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule-1 (KIM-1) levels will be measured and normalized to urinary creatinine. Biomarker changes will be compared between patients undergoing surgery in 30° and 45° Trendelenburg positions. The study seeks to determine whether these biomarkers can detect early renal injury before clinically significant changes in serum creatinine occur.

Eligibility

Primary outcome measure(s)

• Perioperative Changes in Urinary Renal Tubular Injury Biomarkers — Baseline (after induction of anesthesia and urinary catheterization) and postoperative 6 hours.
  Perioperative changes in urinary neutrophil gelatinase-associated lipocalin (NGAL)/creatinine and kidney injury molecule-1 (KIM-1)/creatinine ratios from baseline (after induction of anesthesia and urinary catheterization) to the sixth postoperative hour. Biomarker changes will be compared between participants undergoing surgery in approximately 30° and 45° Trendelenburg positions

Trial sites (1)

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