In this study, the investigators want to examine the effects of intravenous anesthetic drugs and gases on cognitive functions in the postoperative period in individuals who will undergo surgery for obesity. The investigators believe that the anesthesia method we apply with inhalation gases is also as reliable method as total intravenous anesthesia for postoperative cognitive functions in these patients who undergoe sleeve gastrectomy.
The anesthesia method applied intravenously and with inahalational gases have been applied safely for many years. Comparisons between these two anesthesia technics in obese individuals and for postoperative cognitive dysfunctions are limited.
Studies on the examination of cognitive functions in postoperative patients have gained momentum with the use of neuropsychiatric tests performed on patients who have undergone cardiac surgery and these tests have also been performed on individuals who have undergone non-cardiac surgery. And yet, similar declines in cognitive functions have been observed. For these reasons, the effects of surgery itself and anesthesia methods on cognitive functions have been studied up to date.
In this study, the investigators plan to evaluate patients who will undergo obesity surgery in both anesthesia methods by the recovery times from anesthesia and the residual effects of anesthesia, and after awakening they plan to evaluate their cognitive functions with neuropsychiatric tests that will be performed at certain intervals.
Eligibility
Sex
ALL
Min age
18 Years
Max age
65 Years
Healthy volunteers
No
Inclusion Criteria:
Patients of both sexes, Patients Aged between 18 and 65 years, Patients classified as ASA(American Society of Anesthesiologists) physical status I- III, Patients with a BMI (Body Mass Index) between 35 and 50 kg/m² scheduled to undergo sleeve gastrectomy as a type of bariatric surgery for the first time.
Exclusion Criteria:
Patients classified as ASA physical status 4 or high, Patients with known allergy to any of the drugs used in the study, Patients with bleeding disorders, Patients with serum creatinine levels \>2 mg/dL, Patients with severe arrhythmias and EF\<30%, Patients with a known history of drug abuse are excluded.
Primary outcome measure(s)
detecting postoperative delirium, delayed neurocognitive recovery and POCD (postoperative neurocognitive disorder) — Mini Mental State Examination(MMSE) Score and Addenbrooke's Cognitive Examination(ACE) Score Preoperative baseline (1 day before surgery), postoperative 1st, 6th, 12th, and 24th hours, postoperative 3rd and 7th days, and postoperative 1st and 3rd months. Primary Outcome Measure 1:
Time to Eye Opening After Cessation of Anesthetics The time from discontinuation of anesthetic agents to spontaneous eye opening in response to verbal stimulation will be recorded.
Time Frame: From cessation of anesthetic agents until eye opening at the end of surgery.
Primary Outcome Measure 2:
Time to Obey Verbal Commands After Cessation of Anesthetics The time from discontinuation of anesthetic agents until the patient obeys simple verbal commands will be recorded.
Time Frame: From cessation of anesthetic agents until obeying verbal commands at the end of surgery.
Primary Outcome Measure 3:
Time to Extubation The time from discontinuation of anesthetic agents until successful tracheal extubation will be recorded.
Time Frame: From cessation of anesthetic agents until extubation at the end of surgery.
Primary Outcome Measure 4:
Time to Reach Aldrete Recovery Score 9-10 The time required to achieve an Aldrete Recovery Score of 9-10 in the post-anes
Trial sites (1)
Facility
City
Region
Status
Şehit Prof. Dr. İlhan Varank Sancaktepe Training and Research Hospital
Istanbul
Sancaktepe
Recruiting
More Sehit Prof. Dr. Ilhan Varank Sancaktepe Training and Research Hospital trials in Turkey
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
We use cookies to analyse site traffic and improve your experience. With your consent, we may also use cookies for advertising. You can change your choice at any time.