The goal of this observational study is to learn whether the size and shape of the prostatic urethra and seminal vesicles - measured on multiparametric prostate MRI (mpMRI) - are related to premature ejaculation (PE) severity in men aged 18-55.
The main questions it aims to answer are:
* Do men with premature ejaculation have different prostatic urethral length and angulation compared to men without PE?
* Do men with premature ejaculation have different seminal vesicle dimensions compared to men without PE?
* Do prostatic urethra and seminal vesicle measurements on mpMRI correlate with PE severity scores (PEDT) and ejaculation latency time (IELT)?
Researchers will compare men with premature ejaculation to healthy men without ejaculatory complaints to see if specific anatomical features are associated with PE severity.
Participants will:
* Undergo a multiparametric prostate MRI that is already scheduled as part of their routine medical care
* Complete validated questionnaires about ejaculation and sexual function (PEDT, PEP, IELT, IIEF-15)
* Provide a blood sample for routine hormone level measurements
Eligibility
Sex
MALE
Min age
18 Years
Max age
55 Years
Healthy volunteers
Accepted
Inclusion Criteria:
* \- Male aged 18 to 55 years
* In a stable, heterosexual, monogamous relationship with the same female partner for at least 6 months
* Normal erectile function defined as IIEF-15 erectile function domain score ≥26
* Scheduled for clinically indicated multiparametric prostate MRI due to elevated PSA or hematospermia
* Not using any medication that may affect sexual function or psychological status (e.g., SSRIs, PDE5 inhibitors)
Exclusion Criteria:
* Any major psychiatric or somatic disorder
* Hormonal disorders such as hypothyroidism or hyperthyroidism
* Erectile dysfunction (IIEF-15 erectile function domain score \<26)
* Age below 18 or above 55 years
Primary outcome measure(s)
Correlation Between Prostatic Urethral Length and Premature Ejaculation Severity — At enrollment (single time point) Pearson or Spearman correlation between prostatic urethral length measured on mpMRI (mm) and PEDT score. Higher PEDT score indicates greater PE severity (range 0-20).
Correlation Between Seminal Vesicle Dimensions and Premature Ejaculation Severity — At enrollment (single time point) Pearson or Spearman correlation between seminal vesicle anterior-posterior length and superior-anterior length measured on mpMRI (mm) and PEDT score. Higher PEDT score indicates greater PE severity (range 0-20).
Correlation Between Prostatic Urethral Angulation and Intravaginal Ejaculation Latency Time — At enrollment (single time point) Pearson or Spearman correlation between prostatic urethral angulation measured on mpMRI (degrees) and IELT (seconds). Lower IELT indicates greater PE severity.
Trial sites (1)
Facility
City
Region
Status
Başakşehir Çam and Sakura City Hospital, Department of Urology
Istanbul
Istanbul
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This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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