The Role of Urinary RhoA, NGF, and BDNF Levels in Overactive Bladder and Vitamin D Deficiency

NCT07513363 · tracked via the Priya Life Science Turkey tracker

Sponsor

Tarik Emre Sener

Phase

Not applicable

Started

2026-05-01

Last updated

2026-04-07

Condition(s) studied

Overactive BladderVitamin D Deficiency

Investigational drug(s) / intervention(s)

Urotherapy

Urotherapy: Diagnosis and first-line treatment (urotherapy) will be conducted per European Association of Urology (EAU) guidelines.

Study summary

The primary aim of this study is to evaluate the role of three specific urinary proteins-RhoA, Nerve Growth Factor (NGF), and Brain-Derived Neurotrophic Factor (BDNF)-as potential biomarkers for the diagnosis and follow-up of children aged 4-18 diagnosed with Overactive Bladder (OAB) and Vitamin D deficiency.

Eligibility

Sex

ALL

Min age

—

Max age

18 Years

Healthy volunteers

Accepted

Inclusion Criteria: * Children aged 4-18 years presenting with active OAB symptoms (frequency, urgency) Exclusion Criteria: * Neurological diseases * Malignancy * Active urinary tract infections * Anatomical bladder anomalies * History of prior OAB treatment/urological surgery.

Primary outcome measure(s)

Changes in Urinary Biomarker Levels: * Quantitative measurement of urinary RhoA, NGF (Nerve Growth Factor), and BDNF (Brain-Derived Neurotrophic Factor) levels using the ELISA method. — One year

Trial sites (1)

Facility	City	Region	Status
Marmara University School of Medicine Urology Department	Pendik	Istanbul

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07513363 on ClinicalTrials.gov ↗ ← All trials in Turkey