Effect of Neuromuscular Block Depth on Driving Pressure and Postoperative Respiratory Events in Abdominal Surgeries

NCT07464288 · tracked via the Priya Life Science Turkey tracker

Sponsor

Ankara City Hospital Bilkent

Phase

Not applicable

Started

2026-03-23

Last updated

2026-03-17

Condition(s) studied

Driving PressureNeuromuscular Blockade MonitoringPostoperative Respiratory Complications

Investigational drug(s) / intervention(s)

Rocuronium →

Rocuronium: Rocuronium will be administered intravenously as bolus and continuous infusion to achieve target neuromuscular blockade depth according to group allocation. Neuromuscular function will be monitored using quantitative TOF monitoring.

Study summary

This randomized controlled study aims to evaluate the effects of deep versus moderate neuromuscular blockade on intraoperative driving pressure and the development of postoperative critical respiratory events in patients undergoing abdominal surgery under general anesthesia.

Eligibility

Sex

ALL

Min age

18 Years

Max age

—

Healthy volunteers

Accepted

Inclusion Criteria: * Elective abdominal surgery under general anesthesia that is expected to last longer than one hour * ASA I-II-III * Age ≥18 years * Written informed consent Exclusion Criteria: * Refusal to participate in the study * ASA ≥ IV * Age \<18 * Obesity (BMI\>30) and cachexia (BMI \<18) * Laparoscopic surgery * Emergency procedure * Allergy to drugs used during induction and maintenance of general anesthesia * Presence of psychiatric/neurologic/neuromuscular disease * Risk of malignant hyperthermia or having any relative with history of malignant hyperthermia * Use of medications that may affect neuromuscular function (anticonvulsants, aminoglycosides, magnesium salts, etc.) * Pregnancy * Presence of advanced chronic lung disease (asthma, COPD, etc.) * Presence of advanced liver and renal disease (creatinine\>1.6, liver function tests above twice the normal range)

Primary outcome measure(s)

Mean Intraoperative Driving Pressure — From immediately after intubation until the end of surgery (intraoperative period)
Driving pressure will be calculated as plateau pressure minus positive end-expiratory pressure (PEEP) during volume-controlled ventilation. Measurements will be recorded at 30-minute intervals throughout surgery, and the mean value per patient will be calculated.

Trial sites (1)

Facility	City	Region	Status
Ankara Bilkent City Hospital	Ankara	Çankaya

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07464288 on ClinicalTrials.gov ↗ ← All trials in Turkey