Perineural Dextrose Versus Local Anesthetic Injections in Knee Osteoarthritis

NCT07381621 · tracked via the Priya Life Science Turkey tracker

Sponsor

Ankara Training and Research Hospital

Phase

Observational

Started

2026-02-02

Last updated

2026-09-09

Condition(s) studied

Knee Osteoarthritis

Investigational drug(s) / intervention(s)

Perineural 5% Dextrose InjectionPerineural Local Anesthetic Injection

Perineural 5% Dextrose Injection: Perineural injection of 5% dextrose solution administered around periarticular sensory nerves of the knee as part of routine clinical practice.

Perineural Local Anesthetic Injection: Perineural injection of local anesthetic administered around periarticular sensory nerves of the knee as part of routine clinical practice.

Study summary

This prospective observational study aims to compare the clinical effectiveness of perineural 5% dextrose injections and perineural local anesthetic injections in patients with symptomatic knee osteoarthritis. Adult patients receiving routine perineural injection therapy will be followed for six months. Pain intensity and functional outcomes will be assessed at baseline and at 1, 3, and 6 months after treatment using validated clinical assessment tools.

Eligibility

Sex

ALL

Min age

40 Years

Max age

65 Years

Healthy volunteers

Inclusion Criteria: * Symptomatic knee osteoarthritis * Clinical/radiological diagnosis * Knee pain ≥ 3 months * Written informed consent Exclusion Criteria: * Prior knee surgery * Recent intra-articular injection * Inflammatory rheumatic disease * Severe systemic or neurological disease * Pregnancy or breastfeeding

Primary outcome measure(s)

Change in Knee Pain Intensity (Visual Analog Scale [VAS]) — Baseline, 1 month, 3 months, and 6 months
Change in Knee Pain Intensity (Visual Analog Scale \[VAS\]) Change from baseline in knee pain intensity measured using the Visual Analog Scale (VAS), a 100-mm horizontal line anchored at 0 = no pain and 100 = worst imaginable pain; higher scores indicate worse pain.

Trial sites (2)

Facility	City	Region	Status
Ankara Training and Research Hospital Ankara, Altindag, Turkey, 06230	Ankara	Altindag	Not Yet Recruiting
Ankara Training and Research Hospital Ankara, Altindag, Turkey, 06230	Ankara	Altindag	Recruiting

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Other trials for the same condition

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07381621 on ClinicalTrials.gov ↗ ← All trials in Turkey