High-Intensity Interval TrainingModerate-Intensity Continuous Exercisecontrol group
High-Intensity Interval Training: Patients will be trained at 80% to 100% of their maximum heart rate. For the first 4 weeks, they will train at 80% of their maximum heart rate, then at 85%, 90%, 95%, and finally 100%. This protocol will consist of 4 active periods of 4 minutes each at 80% to 100% of maximum heart rate (percentage to be determined weekly) and 3 rest periods of 3 minutes each at 60-70% of maximum heart rate (4x4 minutes). Each session will include a 5-minute warm-up before HIIT and a 5-minute cool-down after HIIT, for a total exercise time of 35 minutes.
Moderate-Intensity Continuous Exercise: Patients will be trained for 30 minutes at 50% to 70% of their maximum heart rate and with an RPE of 11-13. Each session will include a 5-minute warm-up before MCIT and a 5-minute cool-down after MCIT, for a total exercise time of 40 minutes.
control group: They will be given information and education about their illnesses and will be advised to continue their current medical treatment and attend their follow-up appointments regularly.
Study summary
This study aimed to investigate the effects of high-intensity intermittent exercise and moderate-intensity continuous exercise on serum irisin levels, disease activity, functional status, and quality of life in patients with axial spondyloarthritis.
Eligibility
Sex
ALL
Min age
18 Years
Max age
50 Years
Healthy volunteers
Accepted
Inclusion Criteria:
* Patients diagnosed with axillary spondyloarthropathy according to ASAS diagnostic criteria,
* Having a high disease severity (ASDAS-CRP above 2.1),
* Being sedentary (not engaging in physical activity at least 3 days a week in the last 3 months),
* Having no change in ankylosing spondylitis medical treatment in the last 3 months,
* Not having any orthopedic, neurological, cardiovascular, or mental disease that would affect exercise,
* Not using any assistive devices for ambulation,
* Having a BMI of 25 kg/m2 or less,
* Male and female patients aged 18-50 years.
Exclusion Criteria:
* Those with uncontrolled cardiopulmonary disease (such as hypertension, chronic obstructive pulmonary disease, heart failure),
* Having comorbidities that reduce exercise capacity,
* Pregnancy,
* Malignancy,
* Those with a recent history of surgery,
* Those who have engaged in regular exercise (aquatic exercise, land exercise, etc.) in the previous 3 months
Primary outcome measure(s)
serum irisin level — Before treatment and after treatment (week 8) Blood samples will be taken from patients one day before the start of treatment, after a 12-hour fast, and again the morning after a 12-hour fast, immediately after the end of treatment. The collected blood samples will be centrifuged at 1500 g for 10 minutes to obtain serum. The obtained serum will be stored at -80°C until the day of the study. The aim of these serum samples is to determine the level of irisin.
Trial sites (1)
Facility
City
Region
Status
Kırşehir Ahi Evran Üniversitesi
Kırşehir
Turkey (Türkiye)
More Kirsehir Ahi Evran Universitesi trials in Turkey
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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