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Clinical Trials in Turkey / NCT07279402
Recruiting Observational

TRIMPACT: Real-World First-Line Atezolizumab Use in Stage IV NSCLC With PD-L1 ≥50%

NCT07279402 · tracked via the Priya Life Science Turkey tracker
Phase
Observational
Started
2025-09-15
Last updated
2026-04-30

Condition(s) studied

NSCLC Stage IVPD-L1 Gene MutationAtezolizumabReal World Study

Study summary

This prospective, multicenter, real-world observational study aims to evaluate the clinical outcomes of first-line atezolizumab monotherapy in patients with stage IV non-small cell lung cancer (NSCLC) with PD-L1 tumor cell expression ≥50% and no targetable mutations. The study aim to determine how atezolizumab performs in routine clinical practice with respect to survival, treatment response, and safety outcomes in this patient population in Türkiye.

Eligibility

Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria: * Signed informed consent form. * Diagnosis of stage IV non-small cell lung cancer. * Male or female patients aged 18 years or older. * Patients who have been prescribed atezolizumab in accordance with routine clinical practice and the locally approved indication in Türkiye. * Patients who have received up to 3 cycles of atezolizumab at the screening visit. Exclusion Criteria: * Patients who are not receiving atezolizumab for the treatment of lung cancer according to standard of care and the approved indication. * Known or suspected hypersensitivity to atezolizumab. * Pregnant or breastfeeding women.

Primary outcome measure(s)

Trial sites (25)

FacilityCityRegionStatus
Adana City Hospital Adana Turkey (Türkiye) Recruiting
Afyonkarahisar Health Sciences University Hospital Afyonkarahisar Turkey (Türkiye) Recruiting
Ankara Oncology Training and Research Hospital Ankara Turkey (Türkiye) Not Yet Recruiting
Memorial Ankara Hospital Ankara Turkey (Türkiye) Not Yet Recruiting
Ankara Bilkent City Hospital Ankara Turkey (Türkiye) Not Yet Recruiting
Ankara Atatürk Sanatoryum Training and Research Hospital Ankara Turkey (Türkiye) Recruiting
Antalya Training and Research Hospital Antalya Turkey (Türkiye) Recruiting
Antalya City Hospital Antalya Turkey (Türkiye) Recruiting
Adnan Menderes University Faculty of Medicine Hospital Aydin Turkey (Türkiye) Recruiting
Dicle University Hospital Diyarbakır Turkey (Türkiye) Not Yet Recruiting
Trakya University Faculty of Medicine Hospital Edirne Turkey (Türkiye) Recruiting
Gaziantep City Hospital Gaziantep Turkey (Türkiye) Recruiting
Bahçelievler Memorial Hospital Istanbul Turkey (Türkiye) Not Yet Recruiting
İstanbul Medipol Mega Hospital Istanbul Turkey (Türkiye) Not Yet Recruiting
Ümraniye Training and Research Hospital Istanbul Turkey (Türkiye) Not Yet Recruiting
Marmara Üniversitesi Pendik Eğitim ve Araştırma Hastanesi Istanbul Turkey (Türkiye) Not Yet Recruiting
Başakşehir Çam and Sakura City Hospital Istanbul Turkey (Türkiye) Recruiting
Dokuz Eylul University Faculty of Medicine Hospital Izmir Turkey (Türkiye) Recruiting
Ege University Hospital Izmir Turkey (Türkiye) Recruiting
Necmettin Erbakan University Meram Faculty of Medicine Hospital Konya Turkey (Türkiye) Recruiting
Mersin University Faculty of Medicine Hospital Mersin Turkey (Türkiye) Recruiting
Ordu State Hospital Ordu Turkey (Türkiye) Not Yet Recruiting
Sakarya University Faculty of Medicine Hospital Sakarya Turkey (Türkiye) Recruiting
Medical Park Samsun Hospital Samsun Turkey (Türkiye) Not Yet Recruiting
Karadeniz Technical University Farabi Hospital Trabzon Turkey (Türkiye) Recruiting

More Antalya Training and Research Hospital trials in Turkey

Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07279402 on ClinicalTrials.gov ↗ ← All trials in Turkey