External Oblique Intercostal Block (EOICB) for Laparoscopic Cholecystectomy

Condition(s) studied

Investigational drug(s) / intervention(s)

Paravertebral Block (PVB): Ultrasound-guided bilateral thoracic paravertebral block performed after induction of general anesthesia using 0.25% bupivacaine, 20 mL per side (total 40 mL).

External Oblique Intercostal Block (EOI Block): Ultrasound-guided bilateral external oblique intercostal block performed after induction of general anesthesia with 0.25% bupivacaine, 20 mL per side (total 40 mL), injected between the external oblique and intercostal muscles.

Tramadol IV Patient-Controlled Analgesia (PCA): Intravenous patient-controlled analgesia (PCA) programmed to deliver tramadol with a maximum dose of 400 mg in 24 hours. Standard analgesia protocol includes IV paracetamol 1 g every 8 hours.

Study summary

This single-center, prospective, randomized controlled trial aims to compare the effects of paravertebral block (PVB), external oblique intercostal (EOI) block, and intravenous patient-controlled analgesia (PCA) with tramadol on postoperative pain and opioid consumption in patients undergoing elective laparoscopic cholecystectomy. The primary endpoint is total tramadol consumption within 24 hours postoperatively. Secondary outcomes include pain scores, additional analgesic use, incidence of nausea/vomiting, mobilization time, and length of hospital stay.

Eligibility

Primary outcome measure(s)

• 24-hour postoperative tramadol consumption — Within the first 24 hours after surgery.
  Total amount of intravenous tramadol administered via PCA within the first 24 hours after surgery.

Trial sites (1)

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