Malnutrition in ChildrenLiver StiffnessSpleen StiffnessShear Wave Elastography
Investigational drug(s) / intervention(s)
Shear Wave Elastography
Shear Wave Elastography: Shear wave elastography will be used to measure liver and spleen stiffness in all participants. The procedure will be performed using standard ultrasound-based elastography protocols by a pediatric radiologist.
Study summary
This prospective observational study aims to evaluate the effect of malnutrition on liver and spleen stiffness in children using shear wave elastography. Two groups of participants will be enrolled: children diagnosed with malnutrition and age-matched healthy controls. Organ stiffness measurements will be compared between the two groups to assess the impact of malnutrition on liver and spleen tissue properties.
Eligibility
Sex
ALL
Min age
1 Month
Max age
18 Years
Healthy volunteers
Accepted
Inclusion Criteria:
* Children aged 6 to 18 years.
* Diagnosis of malnutrition based on World Health Organization (WHO) criteria (for malnutrition group).
* Healthy children without any chronic illness (for control group).
Exclusion Criteria:
* Children with chronic diseases (e.g., liver disease, diabetes, immunocompromised conditions).
* Children who have previously undergone liver or spleen surgery.
* Children with inability to cooperate during elastography measurement.
Primary outcome measure(s)
Liver stiffness value (kPa) — At baseline (single time point assessment) Liver stiffness will be measured in kilopascals (kPa) using shear wave elastography. The average of three valid measurements will be recorded for each participant.
Spleen stiffness value (kPa) — At baseline Spleen stiffness will be measured in kilopascals (kPa) using shear wave elastography. Similar to liver, the average of three valid measurements will be used.
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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